Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NS, United States.
Department of Thoracic/Head and Neck Medical Oncology, The University of Texas - MD Anderson Cancer Center, Houston, TX, United States.
Matrix Biol. 2020 Sep;91-92:8-18. doi: 10.1016/j.matbio.2020.05.001. Epub 2020 May 19.
Tumor progression is marked by dense collagenous matrix accumulations that dynamically reorganize to accommodate a growing and invasive tumor mass. Cancer-associated fibroblasts (CAFs) play an essential role in matrix remodeling and influence other processes in the tumor microenvironment, including angiogenesis, immunosuppression, and invasion. These findings have spawned efforts to elucidate CAF functionality at the single-cell level. Here, we will discuss how those efforts have impacted our understanding of the ways in which CAFs govern matrix remodeling and the influence of matrix remodeling on the development of an immunosuppressive tumor microenvironment.
肿瘤进展的标志是密集的胶原基质积累，这些基质会动态重组以适应不断生长和侵袭的肿瘤团块。癌相关成纤维细胞（CAF）在基质重塑中起着至关重要的作用，并影响肿瘤微环境中的其他过程，包括血管生成、免疫抑制和侵袭。这些发现促使人们努力在单细胞水平上阐明 CAF 的功能。在这里，我们将讨论这些努力如何影响我们对 CAF 控制基质重塑的方式的理解，以及基质重塑对免疫抑制性肿瘤微环境发展的影响。
