Department of Data Analysis, Ghent University, Henri Dunantlaan 1, 9000 Gent, België, Belgium.
Applied Neurophysiology and Pain Unit, SMBNOS Department, Polyclinic General Hospital, Bari Aldo Moro University, Via Amendola 207 A, 70123 Bari, Italy.
Clin Neurophysiol. 2020 Aug;131(8):1755-1766. doi: 10.1016/j.clinph.2020.04.157. Epub 2020 May 15.
Gamma-band oscillations (GBOs) induced by nociceptive stimuli were compared between migraine patients and controls in order to further characterize interictal pain processing in the brain of migraineurs. GBOs were related to subjective pain intensity, years of migraine history and migraine attack frequency and the sources of GBOs were investigated.
Twenty-three migraine patients without aura and 23 controls received a series of laser stimulations on their right forehead and right hand while recording electroencephalographic data (61 electrodes). After each series they indicated the perceived pain. A multitaper time-frequency method was used on artifact-cleaned scalp data and frequency domain beamforming was used to localize the GBOs.
In both groups we observed increases in GBOs around central electrodes, which were not significantly different between groups. The central GBOs were positively associated with the subjective pain ratings in the control group, in accordance with previous studies, but not in the migraine group. Increases in gamma power were observed in the midcingulate cortex.
No evidence was found that GBOs differ between interictal migraine and controls nor that central GBOs represent a neurophysiological correlate of subjective pain in migraine.
We shed light on observations of GBOs during pain processing in interictal migraine.
为了进一步描述偏头痛患者大脑在间歇期的疼痛处理过程，比较了痛觉刺激诱发的γ 波段振荡（GBOs）在偏头痛患者和对照组之间的差异。GBOs 与主观疼痛强度、偏头痛病史年限和偏头痛发作频率有关，并对 GBOs 的来源进行了研究。
23 例无先兆偏头痛患者和 23 例对照组在右额和右手接受一系列激光刺激，同时记录脑电图数据（61 个电极）。每次刺激后，他们会指出感知到的疼痛。对经过去伪迹处理的头皮数据使用多音时频方法，并使用频域波束形成来定位 GBOs。
在两组中，我们都观察到中央电极周围的 GBOs 增加，但两组之间没有显著差异。中央 GBOs 与对照组的主观疼痛评分呈正相关，这与之前的研究一致，但在偏头痛组中则没有。在中扣带皮质中观察到伽马功率的增加。
没有证据表明间歇期偏头痛患者和对照组之间的 GBOs 存在差异，也没有证据表明中央 GBOs 代表偏头痛患者主观疼痛的神经生理相关性。
我们对间歇期偏头痛患者疼痛处理过程中 GBOs 的观察结果进行了阐述。
