Recent advances in electroanalytical methods for the therapeutic monitoring of antiepileptic drugs: A comprehensive review.

Frequency of seizures is often managed by a wide group of antiepileptic drugs. Regarding the pharmacokinetic variability, narrow targeted range, and difficulty of detecting signs of toxicity based on laboratory responses, therapeutic monitoring of antiepileptic drugs can play a pivotal role in optimizing the drug dosage. Electrochemical sensors and biosensors can facilitate analysis of these drugs due to their unique advantages such as fast analysis, sensitivity, selectivity, and low cost. This review article, for the first time, describes the recent advances in electrochemical sensors and biosensors developed for the analysis of antiepileptic drugs. General electrochemical measuring techniques and types of applied electrode substrates were described first. To simplify the work, various chemical and biological modifiers applied to improve the sensitivity and selectivity of the sensors were classified and explained briefly. Finally, the future prospective on the development of electrochemical platforms in the quantification of antiepileptic drugs will be presented.