Pacheco-Soto Blanca T, Porchia Leonardo M, Lara-Vazquez William C, Torres-Rasgado Enrique, Perez-Fuentes Ricardo, Gonzalez-Mejia M Elba
Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, 13 Sur 2901 Col. Volcanes, C.P. 72420 Puebla, Pue, Mexico.
Laboratorio de Investigación en Fisiopatologia de Enfermedades Crónicas, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Delegación Puebla, Km 4.5 Carretera Federal Atlixco-Metepec, C.P. 42730 Atlixco, Puebla, Mexico.
Reumatol Clin (Engl Ed). 2020 Jun 3. doi: 10.1016/j.reuma.2020.03.004.
We performed a meta-analysis to determine the effect Interleukin-6 (IL-6) promoter polymorphism (-174 G>C, -572 G>C, and -597 G>A) have on the development rheumatoid arthritis (RA) by ethnicity.
PubMed, EBSCO, LILACS, and Scopus databases were searched for studies exploring the association between any IL6 polymorphisms and RA until November 2018. Genotype distributions were extracted and, depending on the level heterogeneity, determined by the ψ-based Q test and the Inconsistency Index (I), fixed-effects or random-effects models were used to calculate pooled odds ratios (ORs) with 95% confidence intervals (95%CIs) for the heterozygous, homozygous, dominant, recessive, and allelic genetic models.
From 708 identified publications, 33 were used in this analysis. For the -174 polymorphism, Asians (OR=7.57, 95%CI: 2.28-25.14, OR=5.84, 95%CI: 2.06-16.56, OR=7.21, 95%CI: 2.30-22.63, OR=5.04, 95%CI: 1.78-14.28, OR=6.60, 95%CI: 2.26-19.28, p<.05) and Middle East countries (OR=2.30, 95%CI: 1.10-4.81, OR=2.27, 95%CI: 1.22-4.22, OR=2.29, 95%CI: 1.24-4.23, p<.05) were associated with a significant risk of developing RA. Whereas, for Latinos, the C-allele was associated with a benefit (OR=0.26, 95%CI: .08-.82, OR=.25, 95%CI: .08-.80, p<.05). For the -572 polymorphism, Asians demonstrated a significant association for the homozygous and recessive genetic models (8 studies, OR=1.56, 95%CI: 1.16-2.09, OR=1.63, 95%CI: 1.08-2.45, p<.05). For the -597 polymorphism, no association was observed.
Here, the -174 G>C polymorphism increased the risk of developing RA in Asians and Middle East populations. Interestingly, for Latinos, the polymorphism was associated with a benefit. For the -572 polymorphism, only the Asian population showed an increased risk of developing RA for the CC genotype.
我们进行了一项荟萃分析，以确定白细胞介素-6（IL-6）启动子多态性（-174 G>C、-572 G>C和-597 G>A）按种族对类风湿性关节炎（RA）发病的影响。
检索了PubMed、EBSCO、LILACS和Scopus数据库，以查找2018年11月之前探索任何IL6多态性与RA之间关联的研究。提取基因型分布，并根据异质性水平，通过基于ψ的Q检验和不一致指数（I）确定，使用固定效应或随机效应模型计算杂合子、纯合子、显性、隐性和等位基因遗传模型的合并比值比（OR）及95%置信区间（95%CI）。
从708篇已识别的出版物中，本分析纳入了33篇。对于-174多态性，亚洲人（OR=7.57，95%CI：2.28-25.14，OR=5.84，95%CI：2.06-16.56，OR=7.21，95%CI：2.30-22.63，OR=5.04，95%CI：1.78-14.28，OR=6.60，95%CI：2.26-19.28，p<0.05）和中东国家（OR=2.30，95%CI：1.10-4.81，OR=2.27，95%CI：1.22-4.22，OR=2.29，95%CI：1.24-4.23，p<0.05）患RA的风险显著增加。而对于拉丁裔，C等位基因具有益处（OR=0.26，95%CI：0.08-0.82，OR=0.25，95%CI：0.08-0.80，p<0.05）。对于-572多态性，亚洲人在纯合子和隐性遗传模型中显示出显著关联（8项研究，OR=1.56，95%CI：1.16-2.09，OR=1.63，95%CI：1.08-2.45，p<0.05）。对于-597多态性，未观察到关联。
在此，-174 G>C多态性增加了亚洲人和中东人群患RA的风险。有趣的是，对于拉丁裔，该多态性具有益处。对于-572多态性，仅亚洲人群中CC基因型患RA的风险增加。
