COVID-19 伴神经系统表现的患者的脑脊液中无法检测到 SARS-CoV-2 RNA。
Patients with COVID-19 and neurological manifestations show undetectable SARS-CoV-2 RNA levels in the cerebrospinal fluid.
机构信息
Laboratório de Pesquisa Clínica em Neuroinfecções, Instituto Nacional de Infectologia Evandro Chagas (INI), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.
Laboratório de Vírus Respiratórios e do Sarampo, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.
出版信息
Int J Infect Dis. 2020 Jul;96:567-569. doi: 10.1016/j.ijid.2020.05.123. Epub 2020 Jun 4.
Abstract
We report that patients with COVID-19 displaying distinct neurological disorders have undetectable or extremely low levels of SARS-CoV-2 RNA in the cerebrospinal fluid, indicating that viral clearance precede the neurological involvement. This finding points to the need for the development of more sensitive molecular tests and the investigation of other neurotropic pathogens to exclude concurrent neuroinfection.
摘要
我们报告称，表现出明显神经障碍的 COVID-19 患者的脑脊液中无法检测到或极低水平的 SARS-CoV-2 RNA，表明病毒清除先于神经受累。这一发现表明需要开发更敏感的分子检测方法，并研究其他神经嗜性病原体，以排除并发的神经感染。
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