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本文引用的文献

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Steroid-Responsive Encephalitis in Coronavirus Disease 2019.COVID-19 相关类固醇反应性脑炎。
Ann Neurol. 2020 Aug;88(2):423-427. doi: 10.1002/ana.25783. Epub 2020 Jun 9.
2
Facial diplegia, a possible atypical variant of Guillain-Barré Syndrome as a rare neurological complication of SARS-CoV-2.面瘫，吉兰-巴雷综合征的一种可能不典型变异型，是 SARS-CoV-2 的一种罕见神经系统并发症。
J Clin Neurosci. 2020 Jul;77:230-232. doi: 10.1016/j.jocn.2020.05.016. Epub 2020 May 14.
3
Early Guillain-Barré syndrome in coronavirus disease 2019 (COVID-19): a case report from an Italian COVID-hospital.2019 年冠状病毒病（COVID-19）中的早期吉兰-巴雷综合征：来自意大利 COVID 医院的病例报告。
Neurol Sci. 2020 Jun;41(6):1351-1354. doi: 10.1007/s10072-020-04449-8. Epub 2020 May 12.
4
Plasmapheresis treatment in COVID-19-related autoimmune meningoencephalitis: Case series.COVID-19 相关自身免疫性脑膜脑炎的血浆置换治疗：病例系列。
Brain Behav Immun. 2020 Jul;87:155-158. doi: 10.1016/j.bbi.2020.05.022. Epub 2020 May 7.
5
SARS-CoV-2: "Three-steps" infection model and CSF diagnostic implication.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）：“三步”感染模型及脑脊液诊断意义
Brain Behav Immun. 2020 Jul;87:128-129. doi: 10.1016/j.bbi.2020.05.002. Epub 2020 May 5.
6
Two patients with acute meningoencephalitis concomitant with SARS-CoV-2 infection.两名患有急性脑膜脑炎并伴有新型冠状病毒2019感染的患者。
Eur J Neurol. 2020 Sep;27(9):e43-e44. doi: 10.1111/ene.14298. Epub 2020 May 30.
7
SARS-CoV-2 can induce brain and spine demyelinating lesions.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）可诱发脑和脊髓脱髓鞘病变。
Acta Neurochir (Wien). 2020 Jul;162(7):1491-1494. doi: 10.1007/s00701-020-04374-x. Epub 2020 May 4.
8
Guillain-Barré syndrome as a complication of SARS-CoV-2 infection.吉兰-巴雷综合征作为新型冠状病毒肺炎感染的并发症
Brain Behav Immun. 2020 Jul;87:111-112. doi: 10.1016/j.bbi.2020.04.074. Epub 2020 Apr 28.
9
Status of SARS-CoV-2 in cerebrospinal fluid of patients with COVID-19 and stroke.COVID-19 患者和卒中患者脑脊液中 SARS-CoV-2 的状况。
J Neurol Neurosurg Psychiatry. 2020 Aug;91(8):846-848. doi: 10.1136/jnnp-2020-323522. Epub 2020 Apr 30.
10
Guillain-Barré syndrome related to COVID-19 infection.与新型冠状病毒肺炎感染相关的吉兰-巴雷综合征
Neurol Neuroimmunol Neuroinflamm. 2020 Apr 29;7(4). doi: 10.1212/NXI.0000000000000741. Print 2020 Jul.

COVID-19 伴神经系统表现的患者的脑脊液中无法检测到 SARS-CoV-2 RNA。

Patients with COVID-19 and neurological manifestations show undetectable SARS-CoV-2 RNA levels in the cerebrospinal fluid.

机构信息

Laboratório de Pesquisa Clínica em Neuroinfecções, Instituto Nacional de Infectologia Evandro Chagas (INI), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.

Laboratório de Vírus Respiratórios e do Sarampo, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.

出版信息

Int J Infect Dis. 2020 Jul;96:567-569. doi: 10.1016/j.ijid.2020.05.123. Epub 2020 Jun 4.

DOI:10.1016/j.ijid.2020.05.123
PMID:32505878
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7271861/
Abstract

We report that patients with COVID-19 displaying distinct neurological disorders have undetectable or extremely low levels of SARS-CoV-2 RNA in the cerebrospinal fluid, indicating that viral clearance precede the neurological involvement. This finding points to the need for the development of more sensitive molecular tests and the investigation of other neurotropic pathogens to exclude concurrent neuroinfection.

摘要

我们报告称，表现出明显神经障碍的 COVID-19 患者的脑脊液中无法检测到或极低水平的 SARS-CoV-2 RNA，表明病毒清除先于神经受累。这一发现表明需要开发更敏感的分子检测方法，并研究其他神经嗜性病原体，以排除并发的神经感染。