Manchanda R, Hirsch S R, Barnes T R
University of Western Ontario, Canada.
Br J Psychiatry. 1988 Sep;153:354-8. doi: 10.1192/bjp.153.3.354.
A review of treatment trials with DT gamma E revealed widely discrepant results. Relevant variables were the variety of measures employed for monitoring psychotic symptoms, and the different criteria used to judge the degree of improvement. The authors suggest a uniform outcome criterion for early trials of new treatments, which would generate more consistent and comparable results between studies, and give a stronger indication of the value of the treatment under test. When the data from the various treatment trials of DT gamma E were reanalysed, applying a uniform outcome criterion of improvement of a change of 80% or more on rating-scale score, the results were more consistent than would have been suspected from the original reports.
对使用DTγE进行治疗试验的回顾显示结果差异很大。相关变量包括用于监测精神病症状的多种测量方法，以及用于判断改善程度的不同标准。作者建议为新治疗方法的早期试验制定统一的结果标准，这将使研究之间产生更一致且可比的结果，并更有力地表明受试治疗方法的价值。当对DTγE的各种治疗试验数据重新进行分析时，采用评分量表得分变化80%或更高的改善作为统一结果标准，结果比从原始报告中所推测的更加一致。
