Department of Ophthalmology, Heinrich-Heine-University Düsseldorf , Düsseldorf, Germany.
Department of Ophthalmology, Asklepios Hospital Nord-Heidberg , Hamburg, Germany.
Curr Eye Res. 2021 Jan;46(1):23-30. doi: 10.1080/02713683.2020.1775259. Epub 2020 Jun 7.
Hidradenitis suppurativa (HS) and psoriasis vulgaris (PSO) are chronic inflammatory dermatoses in which proinflammatory cytokines, such as IL-17, play a central role. The prevalence of keratoconjunctivitis sicca (KCS) is commonly higher in PSO than in healthy individuals. This study was thus set up to investigate the prevalence of KCS among patients with HS.
In a cross-sectional study standardized tear film parameters and symptom-oriented questionnaires (OSDI, SPEED) were analyzed in a total of 71 subjects (HS n = 20, PSO n = 20, healthy controls n = 31). Additionally, IL-17 and MMP-9 in the tear film were analyzed. These parameters were correlated to the clinical severity of the skin disease. PSO patients served as inflammatory control group.
There were statistically significant differences in OSDI ( = .003) and SPEED (p ≤ 0.001) between HS and the control group, but not between PSO and controls. For HS, there was a statistically significant correlation between symptoms (OSDI) and the severity of HS according to Hurley stage ( = .023). Tear film concentrations showed significantly increased levels of IL-17 ( = .018), but not MMP-9, in PSO alone compared to the control group.
Data show that subjective complaints of KCS may be associated with HS and correlate with the severity of the respective Hurley stage, but do not involve alterations of tear film MMP-9 and IL-17. Clinicians should remain mindful that ocular complications in HS are often more vague than in psoriatic patients, but dry eye symptoms might be detrimental for the patients' quality of life.
化脓性汗腺炎（HS）和寻常型银屑病（PSO）是两种慢性炎症性皮肤病，其中促炎细胞因子，如白细胞介素 17（IL-17），起着核心作用。干燥性角结膜炎（KCS）在 PSO 中的发病率通常高于健康人群。因此，本研究旨在调查 HS 患者中 KCS 的患病率。
在一项横断面研究中，对总共 71 名受试者（HS 组 20 名，PSO 组 20 名，健康对照组 31 名）的泪膜标准化参数和以症状为导向的问卷（OSDI、SPEED）进行了分析。此外，还分析了泪膜中的 IL-17 和 MMP-9。这些参数与皮肤病的临床严重程度相关。PSO 患者作为炎症对照组。
HS 组与对照组在 OSDI（ = 0.003）和 SPEED（p ≤ 0.001）方面存在统计学差异，但 PSO 组与对照组之间无统计学差异。对于 HS，症状（OSDI）与 Hurley 分期的严重程度之间存在统计学显著相关性（ = 0.023）。与对照组相比，PSO 组的泪膜浓度中 IL-17 显著升高（ = 0.018），但 MMP-9 无显著升高。
数据表明，KCS 的主观症状可能与 HS 相关，并与相应 Hurley 分期的严重程度相关，但不涉及泪膜 MMP-9 和 IL-17 的改变。临床医生应注意，HS 中的眼部并发症通常比银屑病患者更模糊，但干眼症症状可能会对患者的生活质量产生不利影响。
