Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.
Health Sciences Faculty, University of Copenhagen, Copenhagen, Denmark.
Int J Dermatol. 2020 Feb;59(2):216-220. doi: 10.1111/ijd.14651. Epub 2019 Oct 8.
Hidradenitis suppurativa (HS) and psoriasis (PSO) appear to share important pathogenic elements; in spite of this, the co-occurrence of the two has been widely unexplored.
To explore the co-occurrence of HS and PSO, we recorded the number of patients attending the outpatient clinic at the Department of Dermatology, Zealand University Hospital, Roskilde, Denmark, for the ICD10 diagnosis HS (DL73.2) or PSO (DL40.0, DL40.3, DL40.4, DL40.8, and DL40.9). Data were further compared with previously reported Danish national prevalence rates for HS and PSO.
A total of 1,036 patients were included from the outpatient clinic: 440 HS, 624 PSO, and 28 with both diagnoses. In total 6.4% of HS patients had PSO, and 4.5% of PSO patients had HS. HS patients had OR = 2.99 (95% CI 2.04-4.38) of having PSO as compared to the background population. For PSO patients, they had OR = 2.56 (95% CI 1.74-3.77).
We found a strong association between HS and PSO, which implies a possible comorbidity between PSO and HS that has not previously been properly elucidated. Such a connection could be a common inflammatory pathway driven by the increased secretion of IL-12/23 and TNFα that is a hallmark of both diseases.
化脓性汗腺炎（HS）和银屑病（PSO）似乎具有重要的共同发病机制；尽管如此，这两种疾病的同时发生尚未得到广泛探索。
为了探索 HS 和 PSO 的共同发生，我们记录了丹麦罗斯基勒 Zealand 大学医院皮肤科门诊就诊的患者人数，其 ICD10 诊断为 HS（DL73.2）或 PSO（DL40.0、DL40.3、DL40.4、DL40.8 和 DL40.9）。这些数据与之前报道的丹麦全国 HS 和 PSO 的流行率进一步进行了比较。
从门诊诊所共纳入了 1036 名患者：440 名 HS、624 名 PSO 和 28 名同时患有两种疾病。共有 6.4%的 HS 患者患有 PSO，4.5%的 PSO 患者患有 HS。与背景人群相比，HS 患者患有 PSO 的 OR 为 2.99（95%CI 2.04-4.38）。对于 PSO 患者，OR 为 2.56（95%CI 1.74-3.77）。
我们发现 HS 和 PSO 之间存在很强的关联，这意味着 PSO 和 HS 之间可能存在共病，而这以前并未得到适当阐明。这种联系可能是一种共同的炎症途径，其驱动力是两种疾病的特征性标志——IL-12/23 和 TNFα 的分泌增加。
