克拉屈滨转移至人乳：病例报告。
Cladribine transfer into human milk: A case report.
机构信息
Department of Pediatrics, Texas Tech University Health Sciences Center, Amarillo, TX, USA.
Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany/Institute of Clinical Pharmacy and Pharmacotherapy, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
出版信息
Mult Scler. 2021 Apr;27(5):799-801. doi: 10.1177/1352458520912173. Epub 2020 Jun 8.
BACKGROUND
Cladribine is an antimetabolite used for the treatment of relapsing-remitting multiple sclerosis. At present, there are no data available on its use in breastfeeding mothers and its transfer in human milk.
OBJECTIVE
We present a case of a lactating mother who donated her milk samples to study the transfer of cladribine following a 20-mg oral dose.
METHODS
Analysis was done using liquid chromatography-mass spectrometry.
RESULTS
The relative infant dose calculated in this study was 3.06%.
CONCLUSION
This is the first case report suggesting the transfer of cladribine in human milk in measurable quantities. However, caution should be advised during lactation.
背景
克拉屈滨是一种用于治疗复发缓解型多发性硬化症的抗代谢药物。目前，尚无关于其在哺乳期母亲中使用及其在人乳中转移的数据。
目的
我们报告了一例哺乳期母亲的病例，她在口服 20 毫克剂量后捐献了母乳样本，以研究克拉屈滨的转移情况。
方法
使用液相色谱-质谱法进行分析。
结果
本研究中计算的婴儿相对剂量为 3.06%。
结论
这是首例报告提示克拉屈滨可在人乳中以可测量的量转移的病例。然而，哺乳期应谨慎使用。
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