Amsterdam UMC, location VUmc.
University Medical Center Utrecht, The Netherlands.
Acta Orthop. 2020 Oct;91(5):605-610. doi: 10.1080/17453674.2020.1773670. Epub 2020 Jun 8.
Background and purpose - Congenital pseudarthrosis of the tibia (CPT) is caused by local periosteal disease that can lead to bowing, fracturing, and pseudarthrosis. Current most successful treatment methods are segmental bone transport and vascularized and non-vascularized bone grafting. These methods are commonly hampered by discomfort, reoperations, and long-term complications. We report a combination of a vascularized fibula graft and large bone segment allograft, to improve patient comfort with similar outcomes.Patients and methods - 7 limbs that were operated on in 6 patients between November 2007 and July 2018 with resection of the CPT and reconstruction with a vascularized fibula graft in combination with a bone allograft were retrospectively studied. The mean follow-up time was 5.4 years (0.9-9.6). Postoperative endpoints: time to discharge, time to unrestricted weight bearing, complications within 30 days, consolidation, number of fractures, and secondary deformities.Results - The average time to unrestricted weight bearing with removable orthosis was 3.5 months (1.2-7.8). All proximal anastomoses consolidated within 10 months (2-10). 4 of the 7 grafts fractured at the distal anastomosis between 6 and 14 months postoperatively. After reoperation, consolidation of the distal anastomosis was seen after 2.8 months (2-4). 1 patient required a below-knee amputation.Interpretation - This case series showed favorable results of the treatment of CPT through a combination of a vascularized fibula graft and large bone segment allograft, avoiding the higher reintervention rate and discomfort with ring frame bone transport, and the prolonged non-weight bearing with vascularized fibula transfer without reinforcement with a massive large bone segment allograft.
背景与目的 - 先天性胫骨假关节(CPT)是由局部骨膜疾病引起的,可导致弯曲、骨折和假关节。目前最成功的治疗方法是节段性骨搬运和带血管及不带血管的骨移植。这些方法通常受到不适、再次手术和长期并发症的困扰。我们报告了一种带血管腓骨移植和大块骨段同种异体骨移植的联合应用,以提高患者的舒适度,同时获得类似的效果。
患者和方法 - 2007 年 11 月至 2018 年 7 月期间,对 6 例患者的 7 条肢体进行了手术,这些患者均患有 CPT,并采用带血管腓骨移植联合骨同种异体骨移植进行重建。回顾性研究了这些患者的手术情况。平均随访时间为 5.4 年(0.9-9.6 年)。术后终点:出院时间、无限制负重时间、30 天内并发症、骨愈合、骨折次数和继发性畸形。
结果 - 可移动矫形器无限制负重的平均时间为 3.5 个月(1.2-7.8 个月)。所有近端吻合均在 10 个月内(2-10 个月)愈合。7 个移植物中有 4 个在术后 6-14 个月时在远端吻合处发生骨折。再次手术后,远端吻合在 2.8 个月(2-4 个月)后愈合。1 例患者需要进行膝下截肢。
结论 - 本病例系列研究表明,通过带血管腓骨移植和大块骨段同种异体骨移植的联合应用,可以有效地治疗 CPT,避免了环形框架骨搬运的高再干预率和不适感,以及不带血管的腓骨移植的长时间非负重期,同时也不需要大块骨段同种异体骨移植来加强。