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成年后采用带血管腓骨移植治疗持续性先天性胫骨假关节:17年随访

Persistent Congenital Tibial Pseudoarthrosis until Adulthood Treated with Vascularised Fibular Graft: A 17-year Follow-up.

作者信息

Suwannaphisit Sitthiphong, Kawamura Kenji, Omokawa Shohei

机构信息

Department of Orthopaedics, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand.

Department of Orthopaedic Surgery, Nara Medical University, Nara, Japan.

出版信息

J Plast Reconstr Surg. 2024 Nov 22;4(3):137-144. doi: 10.53045/jprs.2024-0032. eCollection 2025 Jul 27.

DOI:10.53045/jprs.2024-0032
PMID:40755475
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12310351/
Abstract

A 39-year-old woman diagnosed with persistent congenital tibial pseudoarthrosis until adulthood presented with a right leg angular deformity, associated pain, and significant limb length discrepancy. Over a 17-year period, the case was closely monitored and treated through excision of the pseudarthrosis, vascularised fibular graft with bone marrow-derived and cultured mesenchymal cells, combined with highly purified β-tricalcium phosphates, internal fixation, and the application of a ring Ilizarov fixator. The successful union of bones and correction of deformities was achieved through consideration of both mechanical and biological aspects.

摘要

一名39岁女性,直到成年才被诊断出患有持续性先天性胫骨假关节,出现右腿成角畸形、相关疼痛和明显的肢体长度差异。在17年的时间里,对该病例进行了密切监测,并通过切除假关节、带骨髓来源和培养间充质细胞的带血管腓骨移植、联合高纯度β-磷酸三钙、内固定以及应用环形伊利扎罗夫固定器进行治疗。通过综合考虑机械和生物学方面,实现了骨的成功愈合和畸形矫正。

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本文引用的文献

1
Anterolateral Tibial Bowing and Congenital Pseudoarthrosis of the Tibia: Current Concept Review and Future Directions.胫骨前外侧弓形弯曲与先天性胫骨假关节:当前概念综述与未来方向
Curr Rev Musculoskelet Med. 2022 Dec;15(6):438-446. doi: 10.1007/s12178-022-09779-y. Epub 2022 Jul 16.
2
Diagnostic and treatment challenge in adult presentation of congenital pseudoarthrosis of the tibia: A case report.成人先天性胫骨假关节表现的诊断与治疗挑战:一例报告
Ann Med Surg (Lond). 2020 Aug 29;58:112-116. doi: 10.1016/j.amsu.2020.08.030. eCollection 2020 Oct.
3
Bone nonunion management in children with a vascularized tibial periosteal graft.
带血管蒂胫骨骨膜移植治疗儿童骨不连。
Microsurgery. 2020 Oct;40(7):760-765. doi: 10.1002/micr.30655. Epub 2020 Sep 19.
4
Combined massive allograft and intramedullary vascularized fibula transfer: the Capanna technique for treatment of congenital pseudarthrosis of the tibia.同种异体骨大段移植结合带血管蒂腓骨移植:Capanna 技术治疗先天性胫骨假关节
Acta Orthop. 2020 Oct;91(5):605-610. doi: 10.1080/17453674.2020.1773670. Epub 2020 Jun 8.
5
Congenital pseudarthrosis of the tibia: the outcome of a pathology-oriented classification system and treatment protocol.先天性胫骨假关节:一种基于病理的分类系统和治疗方案的结果。
J Pediatr Orthop B. 2020 Jul;29(4):337-347. doi: 10.1097/BPB.0000000000000660.
6
Epidemiology and treatment outcome of congenital pseudarthrosis of the tibia.胫骨先天性假关节的流行病学及治疗结果
J Child Orthop. 2013 Mar;7(2):157-66. doi: 10.1007/s11832-012-0477-0. Epub 2013 Jan 18.
7
Congenital pseudarthrosis of the tibia.先天性胫骨假关节。
Orthop Traumatol Surg Res. 2011 Nov;97(7):750-61. doi: 10.1016/j.otsr.2011.09.001. Epub 2011 Oct 12.
8
Orthopaedic manifestations of neurofibromatosis type 1.神经纤维瘤病 1 型的骨科表现。
J Am Acad Orthop Surg. 2010 Jun;18(6):346-57. doi: 10.5435/00124635-201006000-00007.
9
The use of rhBMP-2 for the treatment of congenital pseudarthrosis of the tibia: a case series.重组人骨形态发生蛋白-2用于治疗先天性胫骨假关节:病例系列
J Bone Joint Surg Am. 2010 Jan;92(1):177-85. doi: 10.2106/JBJS.H.01667.
10
Refracture after Ilizarov osteosynthesis in atrophic-type congenital pseudarthrosis of the tibia.伊里扎洛夫骨固定术后胫骨萎缩型先天性假关节的再骨折
J Bone Joint Surg Br. 2008 Apr;90(4):488-93. doi: 10.1302/0301-620X.90B4.20153.