Reproductive Health Research Institute, Santiago, Chile; Translational Psychiatry Laboratory, Clínica Psiquiátrica Universitaria, Hospital Clínico, Universidad de Chile, Santiago, Chile; Millennium Nucleus to Improve the Mental Health of Adolescents and Youths (Imhay), Santiago, Chile.
Tallahassee Community College, Tallahassee, FL, USA.
Trends Endocrinol Metab. 2020 Oct;31(10):742-759. doi: 10.1016/j.tem.2020.04.007. Epub 2020 Jun 5.
Tibolone (TIB), a selective tissue estrogenic activity regulator (STEAR) in clinical use by postmenopausal women, activates hormonal receptors in a tissue-specific manner. Estrogenic activity is present mostly in the brain, vagina, and bone, while the inactive forms predominate in the endometrium and breast. Conflicting literature on TIB's actions has been observed. While it has benefits for vasomotor symptoms, bone demineralization, and sexual health, a higher relative risk of hormone-sensitive cancer has been reported. In the brain, TIB can improve mood and cognition, neuroinflammation, and reactive gliosis. This review aims to discuss the systemic effects of TIB on peri- and post-menopausal women and its role in the brain. We suggest that TIB is a hormonal therapy with promising neuroprotective properties.
替勃龙（TIB）是一种临床用于绝经后妇女的选择性组织雌激素活性调节剂（STEAR），以组织特异性方式激活激素受体。雌激素活性主要存在于大脑、阴道和骨骼中，而无活性形式则主要存在于子宫内膜和乳房中。关于 TIB 的作用存在相互矛盾的文献。虽然它对血管舒缩症状、骨矿物质流失和性健康有好处，但报告称激素敏感型癌症的相对风险更高。在大脑中，TIB 可以改善情绪和认知、神经炎症和反应性神经胶质增生。本综述旨在讨论 TIB 对绝经前和绝经后妇女的全身作用及其在大脑中的作用。我们认为 TIB 是一种具有有前景的神经保护特性的激素治疗药物。
