Departments of Infectious Diseases, Infection Control and Employee Health.
Genitourinary Medical Oncology.
Semin Oncol. 2020 Apr-Jun;47(2-3):165-167. doi: 10.1053/j.seminoncol.2020.04.005. Epub 2020 May 21.
Chronic Hepatitis C virus (HCV) infection has been associated with extrahepatic cancers. Few studies have reported associations between HCV and genitourinary cancers such as kidney and prostate cancers with inconsistent findings. We sought to study associations between HCV and the most common genitourinary cancers including kidney, prostate and urinary bladder.
This case-control study included adult (≥18 years at diagnosis) cancer patients who were screened for HCV antibody (anti-HCV) at MD Anderson Cancer Center from June 2004 through January 2018. Cases had incident primary genitourinary cancers (cancers of the kidney, prostate, renal pelvis and ureter, or urinary bladder). Controls had smoking-associated cancers (esophagus, lung and pancreas). Multivariate logistic regression models were used.
Among 42,244 patients screened for anti-HCV, 1,493 cases (527 kidney, 691 prostate, 58 renal pelvis and ureter, and 217 urinary bladder cancer) and 1,187 controls (242 esophagus, 709 lung, and 236 pancreas cancer) were studied. In the univariate analysis, the prevalence of anti-HCV positivity did not differ significantly between the controls and the cases with cancers of the renal pelvis and ureter (8% v9%, P = .81), prostate (10% v8%, P = .34), or urinary bladder (8% v 6%, P = .18). In contrast, the prevalence of anti-HCV positivity was lower among the cases with kidney cancer than among the controls (4% v 8%, P< .001). However, in the multivariate analyses after adjustment for cofounders, no significant association between anti-HCV positivity and any genitourinary cancer we evaluated.
Our results do not support an association between chronic HCV and common genitourinary cancers.
慢性丙型肝炎病毒（HCV）感染与肝外癌症有关。少数研究报告了 HCV 与肾和前列腺癌等泌尿道癌症之间的关联，但研究结果不一致。我们旨在研究 HCV 与最常见的泌尿道癌症（包括肾脏、前列腺和膀胱癌）之间的关联。
本病例对照研究纳入了 2004 年 6 月至 2018 年 1 月期间在 MD 安德森癌症中心接受 HCV 抗体（抗-HCV）筛查的成年（诊断时≥18 岁）癌症患者。病例组为原发性泌尿道癌（肾脏、前列腺、肾盂和输尿管或膀胱癌）患者。对照组为与吸烟相关的癌症（食管癌、肺癌和胰腺癌）患者。采用多变量逻辑回归模型进行分析。
在 42244 例筛查抗-HCV 的患者中，有 1493 例（527 例肾脏癌、691 例前列腺癌、58 例肾盂和输尿管癌、217 例膀胱癌）和 1187 例（242 例食管癌、709 例肺癌和 236 例胰腺癌）对照组纳入研究。在单变量分析中，对照组与肾盂和输尿管癌（8%比 9%，P=0.81）、前列腺癌（10%比 8%，P=0.34）或膀胱癌（8%比 6%，P=0.18）患者的抗-HCV 阳性率无显著差异。相比之下，肾癌患者的抗-HCV 阳性率低于对照组（4%比 8%，P<0.001）。然而，在调整混杂因素后的多变量分析中，我们评估的抗-HCV 阳性与任何泌尿道癌症之间均无显著关联。
我们的研究结果不支持慢性 HCV 与常见泌尿道癌症之间存在关联。
