Kakizaki H, Abe Y, Sugano O, Kato H
Department of Urology, Yamagata Prefectural Central Hospital.
Nihon Hinyokika Gakkai Zasshi. 1992 Nov;83(11):1841-6. doi: 10.5980/jpnjurol1989.83.1841.
There were 970 patients who were diagnosed as having genitourinary cancer at Yamagata Prefectural Central Hospital between 1975 and 1990, and of whom 100 cases (10.3%) had multiple primary malignant neoplasms in addition to their genitourinary cancer. They were compared with 220 patients having single genitourinary cancer and 274 having benign prostatic hypertrophy without past histories of cancer. The genitourinary organs involved with cancers included the prostate (50 patients), urinary bladder (43 patients), ureter or renal pelvis (15 patients) and kidney (7 patients). In the prostate cancer, the incidental carcinomas occupied 30%. The other organs accompanying the genitourinary cancers included the stomach, lung and colon. In patients of multiple primary cancers, single genitourinary cancer and benign prostatic hypertrophy, positive family histories for cancer were observed in 40.0%, 37.7% and 33.2%, respectively, with no significant difference between these groups. Histories of smoking were observed in 54.0%, 38.2% and 34.3% respectively, with significant difference between the multiple primary neoplasm patients and the other 2 groups (p < 0.01). There were two cases in whom the second cancer could be possibly caused by the exposure to radiation for the first cancer. No oncotherapeutic drugs or occupational exposure could be seriously suspected of the cause of the second cancers in the present cases.
1975年至1990年间，在山形县中央医院被诊断患有泌尿生殖系统癌症的患者有970例，其中100例（10.3%）除泌尿生殖系统癌症外还患有多发性原发性恶性肿瘤。将他们与220例患有单一泌尿生殖系统癌症的患者以及274例无癌症病史的良性前列腺增生患者进行了比较。患有癌症的泌尿生殖器官包括前列腺（50例患者）、膀胱（43例患者）、输尿管或肾盂（15例患者）和肾脏（7例患者）。在前列腺癌中，偶然癌占30%。伴随泌尿生殖系统癌症的其他器官包括胃、肺和结肠。在多发性原发性癌症患者、单一泌尿生殖系统癌症患者和良性前列腺增生患者中，癌症家族史阳性率分别为40.0%、37.7%和33.2%，这些组之间无显著差异。吸烟史分别为54.0%、38.2%和34.3%，多发性原发性肿瘤患者与其他两组之间存在显著差异（p<0.01）。有两例患者的第二种癌症可能是由于第一种癌症接受放疗所致。在本病例中，没有严重怀疑任何肿瘤治疗药物或职业暴露是第二种癌症的病因。
