School of Veterinary Medicine, Louisiana State University, USA.
Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Vet Anaesth Analg. 2020 Jul;47(4):419-436. doi: 10.1016/j.vaa.2019.12.009. Epub 2020 Mar 27.
The objective of this study was to review the scientific articles on the use of nociceptive threshold testing (NTT) in cats and to summarize the clinical and experimental applications in this species.
Pertinent literature was searched with PubMed, Scopus, Web of Science, Universitätsbibliothek Basel (swissbib Basel Bern) and Google Scholar. The search was then refined manually based first on article titles and abstracts, and subsequently on full texts.
Of the four classical acute nociceptive models used for NTT, thermal and mechanical are most commonly used in cats. Thermal stimulation is applicable in experimental settings and has been used in pharmacodynamics studies assessing feline antinociception. Although mechanical stimulation is currently less used in cats, in the future it might play a role in the evaluation of clinical feline pain. However, the low response reliability after stimulus repetition within a narrow time interval represents a major limitation for the clinical use of mechanical thresholds in this species. Challenges remain when thermal thresholds are used to investigate analgesics that have the potential to affect skin temperature, such as opioids and α2-adrenergic agonists, and when a model of inflammatory pain is reproduced in experimental cats with the purpose of evaluating non-steroidal anti-inflammatory drugs as analgesics.
本研究旨在回顾有关猫使用伤害感受阈值测试（NTT）的科学文献，并总结该物种的临床和实验应用。
通过 PubMed、Scopus、Web of Science、巴塞尔大学图书馆（瑞士巴塞尔伯尔尼）和 Google Scholar 搜索相关文献。然后，首先根据文章标题和摘要，随后根据全文对搜索结果进行了人工细化。
在用于 NTT 的四种经典急性伤害感受模型中，热和机械刺激最常用于猫。热刺激适用于实验环境，并已用于评估猫类镇痛作用的药效动力学研究。尽管机械刺激在猫中目前使用较少，但在未来，它可能在评估临床猫类疼痛方面发挥作用。然而，在短时间间隔内重复刺激时，响应可靠性低，这是该物种机械阈值临床应用的主要限制。当使用热阈值来研究可能影响皮肤温度的镇痛药物（如阿片类药物和 α2-肾上腺素能激动剂）时，以及当为评估非甾体抗炎药作为镇痛药而在实验猫中再现炎症性疼痛模型时，仍存在挑战。
