Department of Pediatric Newborn Medicine, Brigham & Women's Hospital, Boston, MA, USA.
Department of Nutrition, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
J Perinatol. 2020 Aug;40(8):1246-1252. doi: 10.1038/s41372-020-0705-2. Epub 2020 Jun 7.
Quantify associations of human milk feeding with in-hospital growth and examine differences by human milk type (maternal or donor).
We included infants born <33 weeks' gestation and <1500 g from 9 Neonatal Intensive Care Units (n = 1429). We estimated associations of percent of visit days fed any human milk (maternal or donor) and percent of days fed donor milk with weight, length, and head z-scores at discharge or transfer using a linear mixed model, adjusting for birth size and other covariates.
Any human milk feeding was not associated with growth outcomes. Infants fed donor milk on ≥50% of days had less favorable growth vs. those fed <50% [z-scores-weight: -1.1 vs. -0.7 (p = 0.04); length: -1.5 vs. -1.1 (p = 0.04); head -1.0 vs. -0.3 (p < 0.01)].
Fortified human milk was not associated with impaired growth compared with preterm formula.
量化母乳喂养与住院期间生长的关系，并按母乳类型（母体或捐赠）进行差异分析。
我们纳入了来自 9 个新生儿重症监护病房（NICU）的胎龄<33 周和体重<1500 克的婴儿（n=1429）。我们使用线性混合模型，根据出生时的大小和其他协变量，估计了任何一天接受人乳（母体或捐赠）的比例和捐赠乳喂养天数的比例与出院或转院时体重、身长和头围 Z 评分的关联。
任何母乳喂养与生长结局均无关联。每天接受≥50%捐赠乳喂养的婴儿与接受<50%捐赠乳喂养的婴儿相比，生长情况较差[体重 Z 评分：-1.1 与 -0.7（p=0.04）；身长：-1.5 与 -1.1（p=0.04）；头围：-1.0 与 -0.3（p<0.01）]。
与早产儿配方奶相比，强化人乳不会导致生长受损。
