Department of Pediatrics, Mount Sinai Hospital, Toronto, ON, Canada.
Maternal-infant Care Research Centre, Mount Sinai Hospital, Toronto, ON, Canada.
J Perinatol. 2020 Nov;40(11):1712-1718. doi: 10.1038/s41372-020-0710-5. Epub 2020 Jun 7.
To compare neurodevelopmental outcomes of extremely preterm children who received soy-medium chain triglycerides-olive-fish oil-containing lipid emulsion (SMOF-LE) vs soy-based LE.
We conducted a pre-post comparative cohort study of children born < 29 weeks' gestation who received > 7 days of LE. Outcomes were mortality/significant neurodevelopmental impairment (NDI), mortality/any NDI, significant NDI, any NDI, and individual components of NDI.
Among children with follow-up data (Intralipid: n = 340/442, 77%; SMOF-LE: n = 214/286, 75%), baseline characteristics were comparable except for postnatal steroids. There was no significant difference in death/significant NDI between groups. Adjusted odds of death/any NDI [0.68 (95% CI 0.48, 0.97)], any NDI [0.64 (95% CI 0.44, 0.93)] and Bayley-III language score < 85 and <70 were significantly lower in the SMOF-LE group.
In extremely preterm children, a change from soy-based LE to SMOF-LE was not associated with deleterious effect on neurodevelopmental outcomes and may have been associated with some improvement.
比较接受大豆-中链甘油三酯-橄榄油-鱼油脂肪乳（SMOF-LE）与大豆基脂肪乳的极早产儿的神经发育结局。
我们进行了一项前后比较队列研究，纳入了接受>7 天脂肪乳治疗的<29 周胎龄出生的儿童。结局为死亡率/显著神经发育障碍（NDI）、死亡率/任何 NDI、显著 NDI、任何 NDI 以及 NDI 的各个组成部分。
在有随访数据的儿童中（Intralipid：n=340/442，77%；SMOF-LE：n=214/286，75%），除了产后类固醇外，基线特征无显著差异。两组间死亡率/显著 NDI 无显著差异。调整后的死亡/任何 NDI 的比值比[0.68（95%CI 0.48，0.97)]、任何 NDI [0.64（95%CI 0.44，0.93)]和 Bayley-III 语言评分<85 和<70 的比值比显著更低。
在极早产儿中，从大豆基脂肪乳转换为 SMOF-LE 并不会对神经发育结局产生有害影响，甚至可能有一定的改善。
