Department of Medical Biotechnology, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Mol Biol Rep. 2020 Aug;47(8):6207-6216. doi: 10.1007/s11033-020-05565-6. Epub 2020 Jun 7.
Synthetic biology breakthroughs have facilitated genetic circuit engineering to program cells through novel biological functions, dynamic gene expressions, as well as logic controls. SynBio can also participate in the rapid development of new treatments required for the human lifestyle. Moreover, these technologies are applied in the development of innovative therapeutic, diagnostic, as well as discovery-related methods within a wide range of cellular and molecular applications. In the present review study, SynBio applications in various cellular and molecular fields such as novel strategies for cancer therapy, biosensing, metabolic engineering, protein engineering, and tissue engineering were highlighted and summarized. The major safety and regulatory concerns about synthetic biology will be the environmental release, legal concerns, and risks of the engineered organisms. The final sections focused on limitations to SynBio.
合成生物学的突破促进了遗传电路工程，通过新的生物学功能、动态基因表达和逻辑控制来对细胞进行编程。SynBio 还可以参与到人类生活方式所需的新治疗方法的快速发展中。此外，这些技术还应用于广泛的细胞和分子应用中，开发创新的治疗、诊断和发现相关方法。在本综述研究中，SynBio 在各种细胞和分子领域的应用，如癌症治疗的新策略、生物传感、代谢工程、蛋白质工程和组织工程，被强调和总结。关于合成生物学的主要安全和监管问题将是环境释放、法律问题和工程生物的风险。最后部分集中讨论了 SynBio 的局限性。
