Department of Neurosciences and Mental Health, Psychiatry Department, Hospital de Santa Maria (CHULN), Lisbon, Portugal.
Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Laterality. 2020 May;25(3):275-284. doi: 10.1080/1357650X.2019.1662431. Epub 2019 Sep 6.
The aim of this study was to determine the rate and types of lifetime psychiatric disorders, as well as their predictors, in a sample of people with refractory epilepsy. Demographic, neurological, psychiatric and neuropsychological data, from people with refractory epilepsy, were registered at the pre-surgical interview. Linear regression was used to determine predictors. One hundred and ninety-one participants were included. Forty-six percent of our sample had at least one previous psychiatric diagnosis, most frequently depressive (64%), anxiety (10%), substance use (10%) and psychotic disorders (6%). Patients with a right-side epileptogenic zone had an increased risk for these disorders (OR 2.36; CI 1.22-4.56; = 0.01). Specific epilepsy-related factors may raise the risk of developing a psychiatric disorder. Our study adds evidence to support a bidirectional relationship between epilepsy and mental health.
本研究旨在确定难治性癫痫患者样本中终生精神障碍的发生率和类型，以及其预测因素。在术前访谈中登记了难治性癫痫患者的人口统计学、神经学、精神科和神经心理学数据。使用线性回归来确定预测因素。共纳入 191 名参与者。我们的样本中有 46%的人至少有过一次以前的精神科诊断，最常见的是抑郁（64%）、焦虑（10%）、物质使用（10%）和精神病障碍（6%）。右侧致痫区的患者发生这些障碍的风险增加（OR 2.36；CI 1.22-4.56； = 0.01）。特定的与癫痫相关的因素可能会增加患精神障碍的风险。我们的研究为癫痫和精神健康之间的双向关系提供了更多证据。
