Palmieri Valentina, Spirito Marco De, Papi Massimiliano
Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy.
Fondazione Policlinico Universitario A. Gemelli IRCSS, Roma, Italy.
Nanomedicine (Lond). 2020 Jun;15(14):1411-1417. doi: 10.2217/nnm-2020-0050. Epub 2020 Jun 8.
Researchers have been creating 3D replicas of damaged tissues for millions of patients by using innovative biomaterials. While these scaffolds have regenerative properties, it would be beneficial if they could be utilized for local therapies, such as for cancer treatment. This report discusses the main advances in graphene scaffold design for near-infrared (NIR) photothermal therapy (PTT). NIR-PTT is a promising alternative for cancer cell killing, mediated by an increase of temperature due to NIR light-absorbers delivered to the tumor proximity. Graphene is a bidimensional material largely exploited in nanomedicine for its unique properties, such as high growth factor loading, which induces cell differentiation and its capacity to absorb NIR light. Here we cover aspects of future research in multifunctional graphene implants for cancer therapy and tissue regeneration.
研究人员通过使用创新生物材料，已经为数百万患者创建了受损组织的3D复制品。虽然这些支架具有再生特性，但如果它们能够用于局部治疗，如癌症治疗，将会很有帮助。本报告讨论了用于近红外（NIR）光热疗法（PTT）的石墨烯支架设计的主要进展。近红外光热疗法是一种很有前景的癌细胞杀伤替代方法，它通过将近红外光吸收剂递送至肿瘤附近，导致温度升高来介导。石墨烯是一种二维材料，因其独特的性质，如高生长因子负载能力（可诱导细胞分化）以及吸收近红外光的能力，而在纳米医学中得到广泛应用。在此，我们涵盖了用于癌症治疗和组织再生的多功能石墨烯植入物未来研究的各个方面。
