Rahmanian Nazanin, Eskandani Morteza, Barar Jaleh, Omidi Yadollah
a Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy , Tabriz University of Medical Sciences , Tabriz , Iran.
J Drug Target. 2017 Mar;25(3):202-215. doi: 10.1080/1061186X.2016.1238475. Epub 2016 Oct 6.
Rapid progresses in nanotechnology fields have led us to use a number of advanced nanomaterials (NMs) for engineering smart multifunctional nanoparticles (NPs)/nanosystems (NSs) for targeted diagnosis and therapy of various diseases including different types of malignancies. For the effective therapy of any type of solid tumor, the treatment modality should ideally solely target the aberrant cancerous cells/tissue with no/trivial impacts on the healthy cells. One approach to achieve such unprecedented impacts can be fulfilled through the use of seamless multimodal NPs/NSs with photoacoustic properties that can be achieved using advanced NMs such as graphene oxide (GO). It is considered as one of the most promising materials that have been used in the development of various NPs/NSs. GO-based targeted NSs can be engineered as programmable drug delivery systems (DDSs) to perform on-demand chemotherapy combined with photonic energy for photothermal therapy (PTT) or photodynamic therapy (PDT). In the current review, we provide important insights on the GO-based NSs and discuss their potentials for the photodynamic/photothermal ablation of cancer in combination with anticancer agents.
纳米技术领域的快速发展促使我们使用多种先进的纳米材料（NMs）来设计智能多功能纳米颗粒（NPs）/纳米系统（NSs），用于包括不同类型恶性肿瘤在内的各种疾病的靶向诊断和治疗。对于任何类型实体瘤的有效治疗，理想的治疗方式应仅靶向异常癌细胞/组织，而对健康细胞无/极小影响。实现这种前所未有的效果的一种方法可以通过使用具有光声特性的无缝多模态NPs/NSs来实现，这可以通过使用诸如氧化石墨烯（GO）等先进的NMs来达成。它被认为是在各种NPs/NSs开发中使用的最有前途的材料之一。基于GO的靶向NSs可以设计为可编程药物递送系统（DDSs），以进行按需化疗，并结合光子能量用于光热疗法（PTT）或光动力疗法（PDT）。在当前的综述中，我们提供了关于基于GO的NSs的重要见解，并讨论了它们与抗癌药物联合用于癌症光动力/光热消融的潜力。
