抗癫痫药物与骨骼健康：当前观念。
Antiepileptic Drugs and Bone Health: Current Concepts.
机构信息
Siniscalchi, Department of Neurology and Stroke Unit, Annunziata Hospital of Cosenza, Cosenza, Italy. Murphy, General Medicine, Stroke Unit, Mater Misericordiae University Hospital, Dublin, Ireland. Cione, Department of Pharmacy, Health and Nutritional Sciences, Department of Excellence 2018-2022, University of Calabria, Rende (CS), Italy. Piro, Orthopedic Unit, Corigliano-Rossano Hospital, ASP Cosenza, Italy. De Sarro and Gallelli, Chair of Pharmacology, Department of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology Unit, Mater Domini University Hospital, Catanzaro, Italy.
出版信息
Psychopharmacol Bull. 2020 May 19;50(2):36-44.
Abstract
Chronic use of antiepileptic drugs (AEDs) can induce the development of adverse effects on bone metabolism. In epileptic patients treated with AED, the monitoring of biochemical markers of bone turnover, such as the measurement of serum 25 (OH) vitamin D, bone mineral density, before the beginning of the treatment and during the follow-up is not routinely required. In the future, monitoring of biochemical markers in epileptic patients treated with AED may help us for adequate prevention therapy.
摘要
慢性使用抗癫痫药物（AED）可引起骨代谢不良反应的发生。在接受 AED 治疗的癫痫患者中，在开始治疗前和随访期间，通常不需要监测骨转换的生化标志物，如血清 25（OH）维生素 D、骨密度的测量。在未来，监测接受 AED 治疗的癫痫患者的生化标志物可能有助于我们进行充分的预防治疗。
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