Hayashi Masatoshi, Endo Yasuhiro, Komura Tomozo, Kimura Sachi, Oka Hisashi
Independent Researcher, Japan.
OAT Agrio, Production Engineering Group, Production Control Division, Naruto, Tokushima 772-0021, Japan.
J Pestic Sci. 2020 May 20;45(2):105-108. doi: 10.1584/jpestics.D19-077.
Flutianil was discovered as a novel fungicide chemically characterized as a cyano-methylene thiazolidine. This chemical showed particularly high fungicidal activities against powdery mildew on various crops. Optimization of the fungicidal performance of the series of synthesized chemicals finally led to the identification of flutianil, which could control powdery mildew diseases. In this report, details of the structure-activity relationships from the lead compound to flutianil are described.
氟噻菌胺是一种新型杀菌剂，其化学特征为氰基亚甲基噻唑烷。这种化学物质对多种作物上的白粉病表现出特别高的杀菌活性。对一系列合成化学物质的杀菌性能进行优化最终导致了氟噻菌胺的鉴定，它可以防治白粉病。在本报告中，描述了从先导化合物到氟噻菌胺的构效关系细节。
