Fiona Elsey Cancer Research Institute, Ballarat, VIC, Australia.
Federation University Australia, Mount Helen, VIC, Australia.
Front Immunol. 2020 May 20;11:949. doi: 10.3389/fimmu.2020.00949. eCollection 2020.
MAIT cells are MR1-restricted T cells that are well-known for their anti-microbial properties, but they have recently been associated with different forms of cancer. Several studies have reported activated MAIT cells within the microenvironment of colorectal tumors, but there is conjecture about the nature of their response and whether they are contributing to anti-tumor immunity, or to the progression of the disease. We have reviewed the current state of knowledge about the role of MAIT cells in colorectal cancer, including their likely influence when activated and potential sources of stimulation in the tumor microenvironment. The prospects for MAIT cells being used in clinical settings as biomarkers or as targets of new immunotherapies designed to harness their function are discussed.
MAIT 细胞是受 MR1 限制的 T 细胞，以其抗微生物特性而闻名，但最近它们与不同形式的癌症有关。几项研究报告称，结直肠肿瘤微环境中存在活化的 MAIT 细胞，但对其反应的性质以及它们是否有助于抗肿瘤免疫或疾病进展存在猜测。我们综述了 MAIT 细胞在结直肠癌中的作用的现有知识，包括它们在激活时可能的影响以及肿瘤微环境中潜在的刺激来源。讨论了 MAIT 细胞作为生物标志物或作为旨在利用其功能的新型免疫疗法的靶点在临床环境中的应用前景。
