从……中分离出的小分子的结构与表征
Structural and Characterization of Small Molecules Isolated from .
作者信息
Mtewa Andrew, Sesaazi Duncan C, Lampiao Fanuel
机构信息
Chemistry Section, Department of Applied Sciences, Institute of Technology, Malawi University of Science and Technology, Blantyre, Malawi.
Pharmbiotechnology and Traditional Medicine Center (PHARMBIOTRAC), Mbarara University of Science and Technology, Mbarara, Uganda.
出版信息
Evid Based Complement Alternat Med. 2020 May 15;2020:1375639. doi: 10.1155/2020/1375639. eCollection 2020.
has been reported to have various medicinal properties including anticancer activities. The plant was collected from the Shire river in Malawi, and two cytotoxic compounds, benzene-1,4-diol and nonanedioic acid, were isolated and characterized for the first time in the leaves and roots of the plant. H NMR, COSY, HSQC, HMBC, 13-C, and LCMS spectroscopic experimental techniques were used to identify the compounds in their pure forms. experiments showed that both compounds do not have AMES toxicity and do not inhibit cytochrome P450 enzymes, but nonanedioic acid acts as a CYP2D6 substrate. This work showed that can be considered to have a role as a source of potential hits and leads to drug development that can be rationally optimized for drugs.
据报道，它具有多种药用特性，包括抗癌活性。该植物采自马拉维的希雷河，首次从该植物的叶和根中分离并鉴定出两种细胞毒性化合物，即苯 -1,4 -二醇和壬二酸。使用核磁共振氢谱（1H NMR）、化学位移相关谱（COSY）、异核单量子相干谱（HSQC）、异核多键相关谱（HMBC）、碳谱（13 -C）和液相色谱 -质谱联用（LCMS）等光谱实验技术对纯形式的化合物进行鉴定。实验表明，这两种化合物均无AMES毒性，且不抑制细胞色素P450酶，但壬二酸可作为CYP2D6底物。这项工作表明，该植物可被视为潜在药物靶点和先导物的来源，有望用于药物开发，并可进行合理优化。
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