Wei Kangkang, Liao Jiangquan, Chang Jiangmeng, Zhang Xiaoqiong, Chen Ming, Du Jinhang
Graduate School Beijing University of Chinese Medicine, Beijing, China.
Department of Cardiology of Integrated Chinese and Western Medicine, China-Japan Friendship Hospital, Beijing, China.
Evid Based Complement Alternat Med. 2020 May 13;2020:5357917. doi: 10.1155/2020/5357917. eCollection 2020.
To analyze the development of cardio-oncology, summarize the research achievements, and provide proposals for its future research.
The web of science database was used to search for "cardio-oncology" and "oncocardiology" related articles from the beginning of the database (1970) to April 5, 2019. Excel 2016 and Cytoscape were used to analyze the trend of cardio-oncology research.
A total of 356 articles were obtained. The number of articles has grown rapidly in recent years. Cardiac injury caused by tumor therapy was a research hotspot ( = 107). Researchers paid more attention to the prevention and treatment of cardiotoxicity ( = 54). Experimental researches were a small part of all studies ( = 72), mainly focusing on the study of cancer drugs' cardiac injury, test indicators of cardiotoxicity, and preventive drugs. The United States ( = 156.25), Italy ( = 48.5), and Canada ( = 23.5) published the most articles, making a great contribution to the development of cardio-oncology.
Cardio-oncology has been developing rapidly and receiving a large amount of research efforts in recent years. Most articles on cardio-oncology were published by the authors from the United States (44%) and Italy (17%), while other countries need to pay more attention to cardio-oncology. As an independent discipline, cardio-oncology is certainly in need of significant progress, but it has formed a basic framework, which has obtained many leading theories and meaningful achievements in diagnostic criteria, diagnostic methods, prevention and treatment, mechanism research, and influencing factor. Cardiac injury of tumor drugs has always been a research hotspot in this discipline, and there is still a lot of research space. The research about detection methods of cardiotoxicity and preventive drugs is gradually increasing. Basic research lags behind, and many mechanisms are still unclear.
分析心脏肿瘤学的发展历程，总结研究成果，并为其未来研究提供建议。
利用科学网数据库检索1970年数据库建立之初至2019年4月5日期间与“心脏肿瘤学”和“肿瘤心脏病学”相关的文章。使用Excel 2016和Cytoscape分析心脏肿瘤学研究趋势。
共获得356篇文章。近年来文章数量增长迅速。肿瘤治疗导致的心脏损伤是研究热点（n = 107）。研究人员更关注心脏毒性的预防和治疗（n = 54）。实验研究在所有研究中占比小（n = 72），主要集中在癌症药物心脏损伤、心脏毒性检测指标及预防药物的研究。美国（n = 156.25）、意大利（n = 48.5）和加拿大（n = 23.5）发表文章最多，为心脏肿瘤学的发展做出了巨大贡献。
近年来心脏肿瘤学发展迅速且受到大量研究关注。心脏肿瘤学的大多数文章由美国（44%）和意大利（17%）的作者发表，其他国家需要更多关注心脏肿瘤学。作为一门独立学科，心脏肿瘤学固然需要取得重大进展，但已形成基本框架，在诊断标准、诊断方法、预防治疗、机制研究及影响因素等方面获得了许多领先理论和有意义的成果。肿瘤药物的心脏损伤一直是该学科的研究热点，仍有很大研究空间。关于心脏毒性检测方法和预防药物的研究逐渐增多。基础研究滞后，许多机制仍不清楚。
