Sherwood James
Green Chemistry Centre of Excellence, Department of Chemistry, University of York, Heslington, YO10 5DD, UK.
Beilstein J Org Chem. 2020 May 13;16:1001-1005. doi: 10.3762/bjoc.16.89. eCollection 2020.
The development and study of new solvents has become important due to a proliferation of regulations preventing or limiting the use of many conventional solvents. In this work, the suitability of the Suzuki-Miyaura reaction to demonstrate the usefulness of new solvents was evaluated, including Cyrene™, dimethyl isosorbide, ethyl lactate, 2-methyltetrahydrofuran (2-MeTHF), propylene carbonate, and γ-valerolactone (GVL). It was found that the cross coupling is often unaffected by the choice of solvent, and therefore the Suzuki-Miyaura reaction provides limited information regarding the usefulness of any particular solvent for organic synthesis.
由于大量法规禁止或限制许多传统溶剂的使用，新型溶剂的开发和研究变得至关重要。在这项工作中，评估了铃木-宫浦反应在证明新型溶剂（包括环戊酮™、二甲基异山梨醇、乳酸乙酯、2-甲基四氢呋喃（2-MeTHF）、碳酸丙烯酯和γ-戊内酯（GVL））用途方面的适用性。结果发现，交叉偶联通常不受溶剂选择的影响，因此铃木-宫浦反应对于任何特定溶剂在有机合成中的用途提供的信息有限。
