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通过使用生物量衍生溶剂γ-戊内酯避免微波辅助 Pd/C 催化反应中的热点。

Avoiding hot-spots in Microwave-assisted Pd/C catalysed reactions by using the biomass derived solvent γ-Valerolactone.

机构信息

Università degli Studi di Siena, Dipartimento di Biotecnologie, Chimica e Farmacia, Siena, 53100, Italy.

Università di Perugia, Laboratory of Green Synthetic Organic Chemistry, Dipartimento di Chimica, Biologia e Biotecnologie, Perugia, 06123, Italy.

出版信息

Sci Rep. 2018 Jul 12;8(1):10571. doi: 10.1038/s41598-018-28458-y.

DOI:10.1038/s41598-018-28458-y
PMID:30002506
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6043498/
Abstract

Herein, we report the use of γ-valerolactone as a new biomass-derived reaction medium for microwave assisted organic synthesis. The interaction of this solvent with microwaves and its heating profile under microwave irradiation has been fully characterized for the first time, demonstrating its stability and the applicability in microwave assisted Pd/C catalysed reactions avoiding the arcing phenomena frequently observed in these conditions. The use of γ-valerolactone demonstrated to be compatible with aliphatic and aromatic amines in the hydrogen transfer Pd/C mediated synthesis of benzimidazoles.

摘要

在这里，我们报告了γ-戊内酯作为一种新的生物质衍生反应介质在微波辅助有机合成中的应用。首次对该溶剂与微波的相互作用及其在微波辐射下的加热特性进行了全面的表征，证明了它的稳定性和适用性，可用于微波辅助 Pd/C 催化反应，避免了在这些条件下经常观察到的电弧现象。γ-戊内酯的使用被证明与脂肪族和芳香族胺在氢转移 Pd/C 介导的苯并咪唑合成中是兼容的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7893/6043498/c246069db6c0/41598_2018_28458_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7893/6043498/3c01fb4dcfa3/41598_2018_28458_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7893/6043498/928d2491dc6a/41598_2018_28458_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7893/6043498/c595d26fcf86/41598_2018_28458_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7893/6043498/10d76a99e345/41598_2018_28458_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7893/6043498/c246069db6c0/41598_2018_28458_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7893/6043498/3c01fb4dcfa3/41598_2018_28458_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7893/6043498/928d2491dc6a/41598_2018_28458_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7893/6043498/c595d26fcf86/41598_2018_28458_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7893/6043498/10d76a99e345/41598_2018_28458_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7893/6043498/c246069db6c0/41598_2018_28458_Fig5_HTML.jpg

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