多发性硬化症与原发性胆汁性胆管炎并存：3例报告。
Concurrence of multiple sclerosis and primary biliary cholangitis: Report of 3 cases.
作者信息
Sattar Mozhgan, Poursadeghfard Maryam
机构信息
Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Caspian J Intern Med. 2020;11(2):223-226. doi: 10.22088/cjim.11.2.223.
BACKGROUND
Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system which damages the myelin and axon. Primary biliary cholangitis (PBC) is a slow progressive liver disease with autoimmune feature in which non-purulent destructive cholangitis and interlobular bile duct destruction occur. Involvement of each of PBC and MS is thought to be related to environmental exposure in genetically susceptible persons.
CASE PRESENTATION
Here, we aim to report 3 women 52, 27 and 51 years old with MS and PBC.
CONCLUSION
Although MS seems to have an association with some autoimmune gastrointestinal disorders such as ulcerative colitis, the concurrence of MS and PBC has been rarely reported.
背景
多发性硬化症（MS）是一种中枢神经系统的自身免疫性疾病，会损害髓鞘和轴突。原发性胆汁性胆管炎（PBC）是一种具有自身免疫特征的缓慢进展性肝病，会发生非化脓性破坏性胆管炎和小叶间胆管破坏。PBC和MS的发病均被认为与遗传易感性个体的环境暴露有关。
病例报告
在此，我们旨在报告3例分别为52岁、27岁和51岁患有MS和PBC的女性。
结论
尽管MS似乎与某些自身免疫性胃肠道疾病如溃疡性结肠炎有关，但MS和PBC同时发生的情况鲜有报道。
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