实验性四氯化碳诱导的肝硬化
Experimental carbon tetrachloride-induced cirrhosis of the liver.
作者信息
Muñoz Torres E, Paz Bouza J I, Abad Hernandez M M, Alonso Martin M J, Lopez Bravo A
机构信息
Department of Pathology, School of Medicine, University of Salamanca, Spain.
出版信息
Int J Tissue React. 1988;10(4):245-51.
PMID:3250938
Abstract
The authors produced an experimental model of cirrhosis by administering carbon tetrachloride (CCl4) intraperitoneally over 46 weeks to female Wistar rats at a dose of 0.2 ml of a solution of CCl4 in 33% mineral oil. The cytotoxic effect on the liver of this substance was evaluated in different developmental stages of the process by macroscopic, microscopic and ultrastructural studies.
摘要
作者通过向雌性Wistar大鼠腹腔内注射四氯化碳（CCl4），剂量为0.2 ml CCl4溶于33%矿物油的溶液，持续46周，建立了肝硬化实验模型。通过宏观、微观和超微结构研究，在该过程的不同发育阶段评估了这种物质对肝脏的细胞毒性作用。
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