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酒精对正常男性外周血流、血小板聚集及去甲肾上腺素分泌的短期影响。

Short-term effects of alcohol on peripheral blood flow, platelet aggregation and noradrenaline output in normal man.

作者信息

Finch M B, Copeland S, Leahey W J, Johnston G D

机构信息

Department of Therapeutics and Pharmacology, Queen's University of Belfast, Northern, Ireland, U.K.

出版信息

Int J Tissue React. 1988;10(4):257-60.

PMID:3250940
Abstract

The effects of acute oral administration of alcohol on finger and forearm blood flow, platelet aggregation and plasma noradrenaline were examined over a three-hour period in a group of healthy male volunteers. Finger blood flow was increased at 15, 30 and 60 min and skin temperature was raised at 30 and 60 min. Digital systolic blood pressure was decreased at 15 and 30 min. No change in forearm blood flow was observed. A linear correlation was observed between finger blood flow, skin temperature and plasma alcohol concentrations. No significant changes were observed in platelet aggregation nor in plasma noradrenaline levels. Alcohol appears to have a greater effect on digital and skin blood flow as compared with muscle blood flow.

摘要

在一组健康男性志愿者中,研究了急性口服酒精在三小时内对手指和前臂血流量、血小板聚集及血浆去甲肾上腺素的影响。手指血流量在15、30和60分钟时增加,皮肤温度在30和60分钟时升高。指收缩压在15和30分钟时降低。未观察到前臂血流量有变化。观察到手指血流量、皮肤温度和血浆酒精浓度之间呈线性相关。血小板聚集及血浆去甲肾上腺素水平未观察到显著变化。与肌肉血流量相比,酒精似乎对指部和皮肤血流量有更大影响。

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