Bengmark S, Göransson G, Idvall J, Zoucas E
Thromb Haemost. 1980 Jul 15;43(3):203-7.
The effect of ethanol intoxication on hemostasis after liver resection was studied in the rat. Plasma levels of ethanol were within the range of those found in ethanol intoxication in man. Bleeding time and blood loss were significantly increased, whereas hemoglobin and hematocrit values were decreased after resection in intoxicated animals compared to controls. APT-times and platelet counts did not differ significantly between the two groups of rats. ADP- and collagen-induced platelet aggregation was slightly inhibited one hour after ethanol administration in non-operated animals. A decrease in pH, such as observed in intoxicated animals, did not affect hemostasis. Distribution of cardiac output was significantly altered ethanol intoxication. Renal blood flow was increased by 54%, blood flow in the hepatic artery by 40% and in the portal vein by 47%.
在大鼠中研究了乙醇中毒对肝切除术后止血的影响。血浆乙醇水平在人类乙醇中毒时的范围内。与对照组相比，中毒动物切除术后出血时间和失血量显著增加，而血红蛋白和血细胞比容值降低。两组大鼠的活化部分凝血活酶时间（APTT）和血小板计数无显著差异。在未手术的动物中，乙醇给药1小时后，二磷酸腺苷（ADP）和胶原诱导的血小板聚集略有抑制。如在中毒动物中观察到的pH值降低并不影响止血。乙醇中毒显著改变了心输出量的分布。肾血流量增加了54%，肝动脉血流量增加了40%，门静脉血流量增加了47%。
