Rossi M A, Garramone A, Dianzani M U
Department of Experimental Medicine and Oncology, University of Turin, Italy.
Int J Tissue React. 1988;10(5):321-5.
4-Hydroxynonenal (HNE), a major aldehyde end-product of lipid peroxidation, induces in vitro a rapid stimulation of rat liver PIP2-phospholipase C. At physiological Ca2+ concentration the effect of the aldehyde is strongly potentiated by guanosine thiotriphosphate (GTP gamma S); GPT gamma S; at higher Ca2+ levels the acceleration of PIP2 breakdown induced by the aldehyde reaches very high values, but is no longer modulated by the presence of GTP gamma S. As the concentration of the aldehyde used (1 micromolar) can be actually reached in tissues, the effects shown in vitro are likely to occur in vivo.
4-羟基壬烯醛（HNE）是脂质过氧化的主要醛类终产物，在体外可诱导大鼠肝脏磷脂酰肌醇-4,5-二磷酸（PIP2）-磷脂酶C的快速激活。在生理钙离子浓度下，鸟苷三磷酸硫代类似物（GTPγS）可显著增强醛类的作用；在较高钙离子水平时，醛类诱导的PIP2分解加速达到很高的值，但不再受GTPγS的调节。由于所用醛类的浓度（1微摩尔）在组织中实际能够达到，因此体外显示的效应很可能在体内发生。
