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中枢神经系统感染

central nervous system infection.

作者信息

Talhelm Collin F, Helms Jessica L, Tran Liem T, Contreras Brian X, Stevens Mark L, Sierra-Hoffman Miguel, Castro-Lainez Miriam T, Deliz Rafael J

机构信息

Texas A&M Detar Family Residency Program, Victoria TX 77901, USA.

Department of Oncology and Hematology, 121 Flint Rock Court, Victoria TX 77904, USA.

出版信息

IDCases. 2020 May 29;21:e00852. doi: 10.1016/j.idcr.2020.e00852. eCollection 2020.

Abstract

A 39 year-old male was residing along the south coast of Texas, the USA, presented with fever, myalgias, headaches, and weight loss for ten days. Symptoms and manifestations progressed to include nuchal rigidity, photophobia, hyponatremia, thrombocytopenia, and transaminitis despite the intravenous administration of ceftriaxone and azithromycin. A lumbar puncture performed in the Emergency Department yielded pleocytosis and glucose cerebrospinal fluid/serum ratio of 0.35, suggestive of meningoencephalitis. Conglomerate data raised the suspicion of meningitis secondary to a zoonotic acquired infection, which was later confirmed to be . Doxycycline is the drug of choice for the suspected disease. After doxycycline administration, the patient improved and was discharged home asymptomatic.

摘要

一名39岁男性居住在美国得克萨斯州的南海岸,出现发热、肌痛、头痛和体重减轻症状达10天。尽管静脉注射了头孢曲松和阿奇霉素,但症状和体征仍进展至包括颈部强直、畏光、低钠血症、血小板减少和转氨酶升高。在急诊科进行的腰椎穿刺显示细胞数增多,脑脊液葡萄糖/血清比值为0.35,提示脑膜脑炎。综合数据引发了对人畜共患获得性感染继发脑膜炎的怀疑,后来得到证实。强力霉素是疑似该病的首选药物。使用强力霉素后,患者病情好转并无症状出院。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f71/7265057/bd041886bfa5/gr1.jpg

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