Qiu Tianyang, Jiang Wei, Yan Pei, Jiao Li, Wang Xibin
Key Laboratory of Fundamental Science for Advanced Machining, Beijing Institute of Technology, Beijing, China.
School of Mechanical Engineering, Beijing Institute of Technology, Beijing, China.
Front Bioeng Biotechnol. 2020 May 19;8:462. doi: 10.3389/fbioe.2020.00462. eCollection 2020.
Bioresorbable polymeric stents have attracted great interest for coronary artery disease because they can provide mechanical support first and then disappear within a desired time period. The conventional manufacturing process is laser cutting, and generally they are fabricated from tubular prototypes produced by injection molding or melt extrusion. The aim of this study is to fabricate and characterize a novel bioresorbable polymeric stent for treatment of coronary artery disease. Polycaprolactone (PCL) is investigated as suitable material for biomedical stents. A rotary 3D printing method is developed to fabricate the polymeric stents. Surface modification of polymeric stent is performed by immobilization of 2-N, 6-O-sulfated chitosan (26SCS). Physical and chemical characterization results showed that the surface microstructure of 3D-pinted PCL stents can be influenced by 26SCS modification, but no significant difference was observed for their mechanical behavior. Biocompatibility assessment results indicated that PCL and S-PCL stents possess good compatibility with blood and cells, and 26SCS modification can enhance cell proliferation. These results suggest that 3D printed PCL stent can be a potential candidate for coronary artery disease by modification of sulfated chitosan (CS).
生物可吸收聚合物支架因其能先提供机械支撑，然后在预期时间段内消失，而在冠状动脉疾病治疗中引起了极大关注。传统制造工艺是激光切割，通常它们由通过注塑成型或熔融挤出生产的管状原型制造而成。本研究的目的是制造并表征一种用于治疗冠状动脉疾病的新型生物可吸收聚合物支架。聚己内酯（PCL）被研究作为生物医学支架的合适材料。开发了一种旋转3D打印方法来制造聚合物支架。通过固定2-N，6-O-硫酸化壳聚糖（26SCS）对聚合物支架进行表面改性。物理和化学表征结果表明，26SCS改性可影响3D打印PCL支架的表面微观结构，但未观察到其力学行为有显著差异。生物相容性评估结果表明，PCL和S-PCL支架与血液和细胞具有良好的相容性，26SCS改性可促进细胞增殖。这些结果表明，通过硫酸化壳聚糖（CS）改性的3D打印PCL支架可能是治疗冠状动脉疾病的潜在候选材料。
