Gomes Sandy Danielle Lucindo, Arcanjo Maria Rosiene Antunes, Silva Francisca Raysse Mesquita, Leal Luzia Kalyne Almeida Moreira, Claro Ana Paula Rosifini Alves, Popat Ketul, Vieira Rodrigo Silveira
Department of Chemical Engineering, Federal University of Ceará, Campus Do Pici, Bloco 709, Fortaleza, CE 60455-760 Brazil.
Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Monsenhor Furtado, 1057, Rodolfo Teófilo, Fortaleza, CE 60430-355 Brazil.
In Vitro Model. 2023 Jun 14;2(5):171-179. doi: 10.1007/s44164-023-00044-1. eCollection 2023 Nov.
The main drawbacks of blood-contacting metallic devices are corrosion and thrombus formation on the surface, so polymeric coatings have been proposed to improve its hemocompatibility. Sulfated chitosan (SC) was obtained from natural chitosan (NC) reaction with chlorosulfonic acid to be used as a coating for metallic surfaces. The sulfated chitosan showed no platelet aggregation, an extended clotting time, and non-toxicity to rat fibroblast L929 cells. In this study, stainless steel (SS) and titanium alloys modified with TiO nanotube (NTT) growth received a NC and SC coating. The titanium surface coated with sulfated chitosan presented the lowest percentage of platelet coverage area. Sulfated chitosan proved to be a promising material for use as a coating for metallic surfaces applied for cardiovascular devices.
与血液接触的金属装置的主要缺点是表面腐蚀和血栓形成，因此有人提出使用聚合物涂层来改善其血液相容性。硫酸化壳聚糖（SC）是通过天然壳聚糖（NC）与氯磺酸反应制得的，用作金属表面的涂层。硫酸化壳聚糖未显示血小板聚集，凝血时间延长，且对大鼠成纤维细胞L929无毒。在本研究中，通过TiO纳米管（NTT）生长改性的不锈钢（SS）和钛合金接受了NC和SC涂层。涂有硫酸化壳聚糖的钛表面呈现出最低的血小板覆盖面积百分比。硫酸化壳聚糖被证明是一种有前途的材料，可作为应用于心血管装置的金属表面涂层。
