Davidson J A, Kippax R L, Dyer P A
North Western Regional Tissue Typing Laboratory, Saint Mary's Hospital, Manchester, UK.
J Immunogenet. 1988 Aug;15(4):227-37. doi: 10.1111/j.1744-313x.1988.tb00425.x.
We report here haplotype frequencies for class I (HLA-A, B), class II (HLA-DR) and class III (Bf) gene products of the major histocompatibility complex (MHC) of man. As in other studies (Bertrams & Baur, 1979; Grange et al., 1981), we have chosen to document all families typed for HLA antigens and Bf phenotypes irrespective of ascertainment. We obtained 1,094 haplotypes from 304 families resident in the North West of England, of which 34.1% had been fully typed for HLA-A,B,DR and Bf polymorphisms. We have been able to find both positive and negative linkage disequilibria for two and three locus haplotypes and have listed the most commonly occurring four locus haplotypes. Our data confirms the position of the complement group between HLA-B and HLA-DR, and we have looked for evidence of segregation distortion of MHC haplotypes.
我们在此报告人类主要组织相容性复合体（MHC）的I类（HLA - A、B）、II类（HLA - DR）和III类（Bf）基因产物的单倍型频率。与其他研究（Bertrams和Baur，1979年；Grange等人，1981年）一样，我们选择记录所有进行了HLA抗原和Bf表型分型的家系，而不考虑其确定方式。我们从居住在英格兰西北部的304个家庭中获得了1094个单倍型，其中34.1%的家系已对HLA - A、B、DR和Bf多态性进行了全面分型。我们能够发现两个和三个基因座单倍型的正向和负向连锁不平衡，并列出了最常见的四个基因座单倍型。我们的数据证实了补体组在HLA - B和HLA - DR之间的位置，并且我们已经寻找了MHC单倍型分离畸变的证据。
