与备解素因子B同种异型BfF1相关的人类白细胞抗原

HLA antigens associated with properdin factor B allotype BfF1.

作者信息

Dyer P A, Klouda P T, Harris R

出版信息

Tissue Antigens. 1981;17(4):362-7. doi: 10.1111/j.1399-0039.1981.tb00716.x.

DOI:10.1111/j.1399-0039.1981.tb00716.x

Abstract

Linkage disequilibrium has been described between HLA-B antigens and allotypes of properdin factor B (Bf). The association between HLA-B and DR antigens and the rate allotype BfF1 was investigated. In 27 HLA-A, B and DR typed individuals only one person was found who was DR3 negative but five who were B18 negative. Family studies showed that in nine cases B18, BfF1 and DR3 segregated as a haplotype; in another family which was B18 negative, BfF1 and DR3 segregated together. It is inferred that the Bf locus is more strongly associated with HLA-DR than with HLA-B.

摘要

已描述了HLA - B抗原与备解素因子B（Bf）的同种异型之间存在连锁不平衡。研究了HLA - B和DR抗原与BfF1同种异型频率之间的关联。在27名进行了HLA - A、B和DR分型的个体中，仅发现1人DR3阴性，但有5人B18阴性。家系研究表明，在9个病例中，B18、BfF1和DR3作为单倍型分离；在另一个B18阴性的家系中，BfF1和DR3一起分离。据推断，Bf基因座与HLA - DR的关联比与HLA - B的关联更强。