Department of Pulmonary and Critical Care Medicine, Staten Island University Hospital, Staten Island, NY - Northwell Health, United States of America.
Department of Medicine, Staten Island University Hospital, Staten Island, NY - Northwell Health, United States of America.
J Crit Care. 2020 Oct;59:32-34. doi: 10.1016/j.jcrc.2020.05.017. Epub 2020 May 29.
The novel coronavirus strain known as SARS-CoV-2 has rapidly spread around the world creating distinct challenges to the healthcare workforce. Coagulopathy contributing to significant morbidity in critically ill patients with SARS-CoV-2 has now been well documented. We discuss two cases selected from patients requiring critical care in April 2020 in New York City with a unique clinical course. Both cases reveal significant thrombotic events noted on imaging during their hospital course. Obtaining serial inflammatory markers in conjunction with anti-phospholipid antibody testing revealed clinically significant Antiphospholipid syndrome (APS). This case series reviews the details preceding APS observed in SARS-CoV-2 and aims to report findings that could potentially further our understanding of the disease.
新型冠状病毒株（SARS-CoV-2）迅速在全球范围内传播，给医护人员带来了巨大的挑战。目前已有大量文献报道，严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）感染可导致危重症患者发生凝血病，进而显著增加发病率。本文讨论了 2020 年 4 月在纽约市接受重症监护的 2 例具有独特临床病程的患者。这两例患者在住院期间的影像学检查中均发现明显的血栓事件。连续检测炎症标志物和抗磷脂抗体检测结果显示存在临床显著的抗磷脂综合征（APS）。本病例系列回顾了 SARS-CoV-2 发生 APS 之前的详细情况，旨在报告可能有助于进一步了解该疾病的发现。
