有烟必有火：炎症驱动 MDS。

Where There's Smoke, There's Fire: Inflammation Drives MDS.

机构信息

Cancer and Cell Biology Graduate Program, Baylor College of Medicine, Houston, TX 77008, USA; Department of Molecular and Cellular Biology, Center for Cell and Gene Therapy, and Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX 77008, USA.

出版信息

Trends Immunol. 2020 Jul;41(7):558-560. doi: 10.1016/j.it.2020.05.007. Epub 2020 Jun 5.

DOI:10.1016/j.it.2020.05.007

PMID:32513619

Abstract

Chronic inflammation has been implicated in myelodysplastic syndrome (MDS); however, its role in disease progression is unclear. In a new study by Muto et al., MDS stem cells sparked with TRAF6-activated innate immune signaling were found to outcompete normal counterparts only when fueled by environmental inflammatory stimuli. Non-canonical NF-κB signaling is implicated in inflammatory synergy and MDS progression.

摘要

慢性炎症与骨髓增生异常综合征（MDS）有关；然而，其在疾病进展中的作用尚不清楚。在 Muto 等人的一项新研究中，研究人员发现，只有在受到环境炎症刺激时，被 TRAF6 激活的先天免疫信号触发的 MDS 干细胞才会与正常细胞竞争，而非典型 NF-κB 信号转导与炎症协同作用和 MDS 进展有关。