Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea.
Biomater Sci. 2020 Jul 7;8(13):3751-3759. doi: 10.1039/c9bm01932d. Epub 2020 Jun 9.
Maintaining durable adhesion between soft tissues and relatively hard implant materials is one of the most elusive technological difficulties in bionic devices due to contact damage between mechanically mismatched materials. Although there are many examples of coexistence of soft and hard tissues in living organisms, relatively little is known about the mechanisms used to overcome mechanical mismatches occurring at the interface between soft and hard tissues. Among the various creatures possessing mechanically mismatched biological tissues, Atrina pectinata is a good model system where the interface between stiff byssal threads and soft tissues is distributed all over an extended organ. In this study, we found a wide distribution of various types of carbohydrates and lectins at the mechanically mismatched interface of the byssus of Atrina using histological methods and proteomics. Reversible and robust interactions between the carbohydrate and lectins at the interface would play a major role in mitigating the contact damage at the Atrina interface. Based on these results, the adhesion between sugar and lectin would be useful to overcome a wide range of contact damage observed in research studies on bionic devices.
由于机械性能不匹配的材料之间存在接触损伤，因此在仿生设备中，将软组织和相对较硬的植入材料牢固地黏附在一起是最难以实现的技术难题之一。尽管生物体中有许多软、硬组织共存的例子，但对于克服软、硬组织界面处机械不匹配所使用的机制，我们知之甚少。在具有机械性能不匹配的生物组织的各种生物中，贻贝是一个很好的模型系统，其中坚硬的足丝和软组织之间的界面分布在一个延伸的器官上。在这项研究中，我们使用组织学方法和蛋白质组学在贻贝的机械不匹配界面处发现了各种类型的碳水化合物和凝集素的广泛分布。界面处碳水化合物和凝集素之间的可逆和牢固相互作用将在减轻贻贝界面处的接触损伤方面发挥主要作用。基于这些结果，糖与凝集素之间的黏附对于克服在仿生设备的研究中观察到的广泛接触损伤将是有用的。
