[肺移植患者闭塞性细支气管炎综合征的预测因素]
[Predictors for the Bronchiolitis Obliterans Syndrome in Lung Transplant Patient].
作者信息
Yang Sijia, Abuduwufuer Abudumailamu, Lv Wang, Bao Feichao, Hu Jian
机构信息
The First Affiliated Hospital, Collage of Medicine, Zhejiang University, Hangzhou 310003, China.
出版信息
Zhongguo Fei Ai Za Zhi. 2020 Jun 20;23(6):496-502. doi: 10.3779/j.issn.1009-3419.2020.101.03.
Abstract
Lung transplantation is the ultimate treatment of end-stage lung disease. After transplantation, the 1-year survival rate is 80%, while the 5-year survival rates remaines at around 50% mainly due to bronchiolitis obliterans syndrome (BOS). BOS is regarded as a fibrosing process in the small airways leading to irreversible airway obstruction. A lot of factors are involved in the development of BOS, such as Ischemia/reperfusion injury, infections, oxidative stress, and acute rejection, etc. Studies have shown that early diagnosis of BOS may improve outcome. It is valuable for the long-term survival of lung transplantation to find out several predictors for the BOS. This article reviews the current state of knowledge on predictors for BOS.
摘要
肺移植是终末期肺病的最终治疗手段。移植后，1年生存率为80%，而5年生存率约为50%，主要原因是闭塞性细支气管炎综合征（BOS）。BOS被认为是小气道的纤维化过程，会导致不可逆的气道阻塞。BOS的发生涉及许多因素，如缺血/再灌注损伤、感染、氧化应激和急性排斥反应等。研究表明，BOS的早期诊断可能改善预后。找出BOS的几个预测指标对肺移植的长期生存具有重要价值。本文综述了BOS预测指标的当前知识状态。
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[Predictors for the Bronchiolitis Obliterans Syndrome in Lung Transplant Patient].[肺移植患者闭塞性细支气管炎综合征的预测因素]
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本文引用的文献
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High circulating CD4CD25FOXP3 T-cell sub-population early after lung transplantation is associated with development of bronchiolitis obliterans syndrome.高循环 CD4CD25FOXP3 T 细胞亚群在肺移植后早期与闭塞性细支气管炎综合征的发生有关。
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