Madill Janet, Aghdassi Ellie, Arendt Bianca, Hartman-Craven Brenda, Gutierrez Carlos, Chow Chung-Wai, Allard Johane
University of Toronto, Lung Transplant Program, University Health Network, Toronto, ON, Canada.
Transplant Rev (Orlando). 2009 Apr;23(2):103-10. doi: 10.1016/j.trre.2009.01.003.
Lung transplantation is the ultimate treatment of end-stage lung disease. After transplantation, the 1-year survival rate is 80%. However, 5-year survival rates drop to 50% due to bronchiolitis obliterans syndrome (BOS). Ischemia/reperfusion injury, infections, and acute rejection are major risk factors contributing to the development of BOS. These risk factors are also associated with increased oxidative stress. Oxidative stress is a condition whereby prooxidants overwhelm the antioxidant defense system and may contribute to the pathogenesis of BOS by inducing more tissue injury and inflammation. This article reviews the current state of knowledge on oxidative stress in lung transplantation and BOS.
肺移植是终末期肺病的最终治疗手段。移植后，1年生存率为80%。然而，由于闭塞性细支气管炎综合征（BOS），5年生存率降至50%。缺血/再灌注损伤、感染和急性排斥是导致BOS发生的主要危险因素。这些危险因素也与氧化应激增加有关。氧化应激是一种促氧化剂压倒抗氧化防御系统的状态，可能通过诱导更多组织损伤和炎症而促成BOS的发病机制。本文综述了肺移植和BOS中氧化应激的当前知识状态。
