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[2020年肿瘤学PET放射性药物的临床与研究]

[Oncology PET radiopharmaceuticals in clinic and research in 2020].

作者信息

Mikecz Pál, Fekete Anikó, Tóth Gyula, Környei József, Bali Tibor, Cservenyák Tibor, Borbély Katalin

机构信息

Chem PET Bt., Debrecen, Hungary.

Orvosi Képalkotó Intézet, Debreceni Egyetem ÁOK, Nukleáris Medicina nem Önálló Tanszék, Debrecen, Hungary.

出版信息

Magy Onkol. 2020 Jun 10;64(2):104-111. Epub 2020 Feb 20.

Abstract

"PET based" molecular imaging has significant role in personalized medicine. New radiopharmaceuticals are continuously introduced into the daily practice of detecting diseases and assessing the effectiveness of therapy. In recent years theragnostic applications have come to the forefront of radiopharmaceutical development. This article discusses, among others, radiopharmaceuticals labelled with 18F and 68Ga isotopes required for the diagnosis of neuroendocrine and prostate tumours, furthermore the inhibitors of the fibroblast activation protein. The increasing variety of metallic radioisotopes (44Sc, 64Cu, 52Mn, 86Y, 89Zr) will help meet the need for new biomarkers and will greatly facilitate the introduction of the new generation of PET radiopharmaceuticals.

摘要

基于正电子发射断层扫描(PET)的分子成像在个性化医疗中发挥着重要作用。新型放射性药物不断被引入到疾病检测和治疗效果评估的日常实践中。近年来,诊疗一体化应用已成为放射性药物研发的前沿领域。本文尤其讨论了用于诊断神经内分泌肿瘤和前列腺肿瘤所需的、标记有18F和68Ga同位素的放射性药物,以及成纤维细胞活化蛋白抑制剂。越来越多的金属放射性同位素(44Sc、64Cu、52Mn、86Y、89Zr)将有助于满足对新生物标志物的需求,并将极大地推动新一代PET放射性药物的引入。

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