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[高等生物适应高温的分子机制。III. 两种利什曼原虫中热休克蛋白的诱导]

[Molecular mechanisms of adaptation to hyperthermia in higher organisms. III. Induction of heat-shock proteins in two Leishmania species].

作者信息

Ul'masov Kh A, Ovezmukhammedov A, Karaev K K, Evgen'ev M B

出版信息

Mol Biol (Mosk). 1988 Nov-Dec;22(6):1583-9.

PMID:3252152
Abstract

The heat-shock proteins (hsp) induction in two species of Leishmania have been investigated. The species studied are parasites of two species of lizards (Lymnodactylus caspins and Agama caucasica) differing by temperature of correspondent ecological niche. Our results show that Leishmania species restricted to high-temperature host (Agama) is capable to synthesize its proteins at extreme temperatures (38, 40 degrees C) with greater intensity. Moreover, the species of Leishmania studied differed by heat-shock proteins pattern, the intensive synthesis of hsp88 and hsp48 being the characteristic features of Leishmania species, restricted to the high-temperature host.

摘要

对两种利什曼原虫中的热休克蛋白(hsp)诱导情况进行了研究。所研究的物种是两种蜥蜴(睫角守宫和高加索鬣蜥)的寄生虫,这两种蜥蜴的相应生态位温度不同。我们的结果表明,局限于高温宿主(高加索鬣蜥)的利什曼原虫物种能够在极端温度(38、40摄氏度)下更强烈地合成其蛋白质。此外,所研究的利什曼原虫物种在热休克蛋白模式上存在差异,hsp88和hsp48的强烈合成是局限于高温宿主的利什曼原虫物种的特征。

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