“非感染性心内膜炎”：一名28岁男性遗传性凝血障碍病例报告
"Noninfective Endocarditis": A Case Report of Hereditary Coagulation Disorders in a 28-Year-Old Male.
作者信息
Reid Gregory, Koechlin Luca, Reuthebuch Oliver, Rüter Florian, Hopfer Helmut, Eckstein Friedrich, Santer David
机构信息
Department of Cardiac Surgery, University Hospital Basel, 4031 Basel, Switzerland.
Institute of Medical Genetics and Pathology, University Hospital Basel, 4031 Basel, Switzerland.
出版信息
Diagnostics (Basel). 2020 Jun 8;10(6):384. doi: 10.3390/diagnostics10060384.
We report a case of a young male who presented with acute limb ischemia after sport. With no prior history of disease, a non-infective endocarditis of the native aortic valve was diagnosed. After surgical valve replacement, the patient suffered from acute myocardial ischemia under phenprocoumon therapy. Anti-coagulant monitoring was subsequently changed to Factor II analysis after a rare Factor VII deficiency and prothrombin mutation (G20210A) was diagnosed.
我们报告一例年轻男性病例，该患者在运动后出现急性肢体缺血。既往无疾病史，诊断为原发性主动脉瓣非感染性心内膜炎。手术换瓣后，患者在苯丙香豆素治疗期间发生急性心肌缺血。在诊断出罕见的凝血因子 VII 缺乏和凝血酶原突变（G20210A）后，抗凝监测随后改为凝血因子 II 分析。
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