乳腺癌切除术后患者的 KI-67 和 LEF-1 表达及其对患者预后的影响。

The expression of KI-67 and LEF-1 in patients after breast cancer resection and its effects on patients' prognosis.

机构信息

Department of General Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, P.R. China.

出版信息

J BUON. 2020 Mar-Apr;25(2):627-633.

PMID:32521845

Abstract

PURPOSE

To investigate the expression of KI-67 and LEF-1 in patients after breast cancer resection and its effects on patients' prognosis.

METHODS

A total of 89 breast cancer patients admitted to the first affiliated Hospital of Shantou University Medical College from January 2010 to February 2013 were enrolled as the study group, and 76 healthy individuals were enrolled as the control group. Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the expression of KI-67 and LEF-1 in the serum. The relationship of the two indexes and clinicopathological data of the breast cancer patients were analyzed. In addition, the diagnostic value of KI-67 and LEF-1 in breast cancer patients was analyzed by receiver operating characteristic (ROC) curves, and their diagnostic value in the postoperative 5-year recurrence was also analyzed. Furthermore, the expression of KI-67 and LEF-1 in patients with postoperative recurrent breast cancer within 5 years was evaluated.

RESULTS

The expression of KI-67 and LEF-1 in the study group was higher than in the control group (p<0.05), and the expression of KI-67 and LEF-1 was significantly related to the tumor size and lymph node metastasis (both p<0.05). ROC curve showed that the area under the curve (AUC) of the diagnostic value of KI-67 and LEF-1 for breast cancer patients was 0.860 and 0.858 respectively, and that of the diagnostic value KI-67 combined with LEF-1 for breast cancer patients was 0.924. In addition, the AUC of the diagnostic value of KI-67 and LEF-1 for the recurrence of breast cancer within 5 years was 0.699 and 0.651, respectively, and that of diagnostic value of KI-67 combined with LEF-1 for the recurrence of breast cancer within 5 years was 0.758. The expression of KI-67 and LEF-1 in patients with recurrent disease within 5 years after operation was higher than in patients without recurrence.

CONCLUSION

The expression of KI-67 and LEF-1 in breast cancer patients is significantly higher than in healthy individuals, which has certain diagnostic value in breast cancer. The expression of the two indexes is related to tumor size and lymph node metastasis, and the survival of patients with high expression of KI-67 and LEF-1 is worse.

摘要

目的

探讨乳腺癌患者术后 KI-67 和 LEF-1 的表达及其对患者预后的影响。

方法

选取 2010 年 1 月至 2013 年 2 月汕头大学医学院第一附属医院收治的 89 例乳腺癌患者作为研究组，另选取同期 76 名健康体检者作为对照组。采用逆转录-聚合酶链反应（RT-PCR）检测血清中 KI-67 和 LEF-1 的表达，分析其与乳腺癌患者临床病理资料的关系。此外，采用受试者工作特征（ROC）曲线分析 KI-67 和 LEF-1 对乳腺癌患者的诊断价值，分析其对术后 5 年复发的诊断价值。进一步评估术后 5 年内复发乳腺癌患者的 KI-67 和 LEF-1 表达情况。

结果

研究组 KI-67 和 LEF-1 的表达高于对照组（P<0.05），且 KI-67 和 LEF-1 的表达与肿瘤大小和淋巴结转移明显相关（均 P<0.05）。ROC 曲线显示，KI-67 和 LEF-1 对乳腺癌患者的诊断价值的曲线下面积（AUC）分别为 0.860 和 0.858，KI-67 和 LEF-1 联合对乳腺癌患者的诊断价值的 AUC 为 0.924。此外，KI-67 和 LEF-1 对术后 5 年内乳腺癌复发的诊断价值的 AUC 分别为 0.699 和 0.651，KI-67 和 LEF-1 联合对术后 5 年内乳腺癌复发的诊断价值的 AUC 为 0.758。术后 5 年内复发患者的 KI-67 和 LEF-1 表达均高于未复发患者。