浸润性乳腺癌患者表观扩散系数与病理特征的相关性

Correlation between apparent diffusion coefficient and pathological characteristics of patients with invasive breast cancer.

作者信息

Chen Yuhui, Wang Jiandong, Zhang Xiuxiu, Yang Wuyao, Chen Hongye, Bao Baoshi, Qiu Yue, Tian Lin

机构信息

Department of General Surgery, The First Medical Center, Chinese PLA General Hospital, Beijing, China.

出版信息

Ann Transl Med. 2021 Jan;9(2):143. doi: 10.21037/atm-20-7746.

BACKGROUND

There is insufficient research on the correlation between the apparent diffusion coefficient and clinicopathological characteristics of breast cancer patients. The present study is to investigate the correlation between the apparent diffusion coefficient and pathological characteristics of patients with invasive breast cancer.

METHODS

From January 2019 to September 2020, 122 cases of invasive breast cancer and 21 cases of benign tumors were retrospectively enrolled. The apparent diffusion coefficient was compared between the two groups, and the correlation between the apparent diffusion coefficient and the pathological characteristics of the patients with invasive breast cancer were analyzed.

RESULTS

Compared with the benign tumor group, the apparent diffusion coefficient in the invasive breast cancer group was significantly lower (0.89±0.17 1.47±0.27 10 mm/s, P=0.000). Using the apparent diffusion coefficient to diagnose patients with invasive breast cancer, the area under receiver operating characteristic (ROC) curve was 0.966±0.021 [95% confidence interval (CI): 0.924-1.000, P=0.000], and the best diagnostic cut-off value was 1.16 (10 mm/s), with sensitivity and specificity of 0.905 and 0.902, respectively. The apparent diffusion coefficient was used to diagnose vascular tumor thrombus in patients with invasive breast cancer. The area under the ROC curve was 0.641±0.068 (95% CI: 0.508-0.774, P=0.047), and the best diagnostic threshold was 0.835 (10 mm/s), with sensitivity and specificity of 0.676 and 0.650, respectively. The apparent diffusion coefficient in patients with high expression of Ki-67 (%) was significantly reduced (0.87±0.17 1.00±0.16 10 mm/s, P=0.000). The apparent diffusion coefficient was not significantly correlated with age, menopause, lesion size, estrogen receptor, progesterone receptor, or lymph node metastasis in patients with invasive breast cancer (P>0.05).

CONCLUSIONS

In patients with invasive breast cancer the apparent diffusion coefficient was significantly reduced. It was able to differentiate invasive breast cancer and vascular tumor thrombus, and was also related to Ki-67 (%) high expression.

背景

关于乳腺癌患者表观扩散系数与临床病理特征之间的相关性研究不足。本研究旨在探讨浸润性乳腺癌患者表观扩散系数与病理特征之间的相关性。

方法

回顾性纳入2019年1月至2020年9月期间的122例浸润性乳腺癌患者和21例良性肿瘤患者。比较两组的表观扩散系数，并分析浸润性乳腺癌患者表观扩散系数与病理特征之间的相关性。

结果

与良性肿瘤组相比，浸润性乳腺癌组的表观扩散系数显著降低（0.89±0.17对1.47±0.27×10⁻³mm²/s，P = 0.000）。采用表观扩散系数诊断浸润性乳腺癌患者，受试者操作特征（ROC）曲线下面积为0.966±0.021[95%置信区间（CI）：0.924 - 1.000，P = 0.000]，最佳诊断截断值为1.16×10⁻³mm²/s，敏感性和特异性分别为0.905和0.902。采用表观扩散系数诊断浸润性乳腺癌患者的血管肿瘤血栓，ROC曲线下面积为0.641±0.068（95%CI：0.508 - 0.774，P = 0.047），最佳诊断阈值为0.835×10⁻³mm²/s，敏感性和特异性分别为0.676和0.650。Ki-67（%）高表达患者的表观扩散系数显著降低（0.87±0.17对1.00±0.16×10⁻³mm²/s，P = 0.000）。浸润性乳腺癌患者的表观扩散系数与年龄、绝经状态、病灶大小、雌激素受体、孕激素受体或淋巴结转移无显著相关性（P>0.05）。