No Significant Effects of and Gene Variants on Tuberculosis Susceptibility in the Chinese Population.

Tuberculosis (TB) is an intricate infectious disease that causes a large number of deaths in the population. Interleukin () and - play functional roles in host resistance to infection. Our aim in this study was to explore the association of and polymorphisms with TB susceptibility in the Western Chinese Han population. The case and control groups comprised 900 TB patients and 1534 healthy controls, respectively, and four single-nucleotide polymorphisms (SNPs) were genotyped in and five SNPs in through the improved multiplex ligation detection reaction method. We found no genetic variants in the or genes that were related to TB susceptibility in the analysis of alleles, genotypes, genetic models, and TB clinical subtypes, except for a trend toward low pulmonary tuberculosis and extrapulmonary tuberculosis susceptibility for the SNPs rs1295686 and rs20541. Our study did not find a link between and polymorphisms and TB susceptibility in the Western Chinese Han population. Therefore, our present data revealed the challenge of applying and SNPs as genetic markers for TB and that increased sample sizes and additional races are needed for further studies.