关于[具体基因名称]基因多态性与肺结核之间可能关联的研究。 （注：原文中“,”处应补充具体基因名称）
Investigation on Probable Association Between , and Genes Polymorphism and Pulmonary Tuberculosis.
作者信息
Li Hong-Miao, Tang Fei, Huang Qian, Pan Hai-Feng, Zhang Tian-Ping
机构信息
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, People's Republic of China.
Department of Interventional Pulmonology and Endoscopic Diagnosis and Treatment Center, Anhui Chest Hospital, Hefei, People's Republic of China.
出版信息
J Inflamm Res. 2022 Aug 8;15:4527-4536. doi: 10.2147/JIR.S374714. eCollection 2022.
OBJECTIVE
Our study aimed to explore the association of , and genes polymorphisms with PTB susceptibility and its clinical features.
METHODS
Nine SNPs were genotyped by improved multiple ligase detection reaction (iMLDR) in 476 PTB patients and 473 controls. The association between these SNPs and PTB risk was analyzed using SPSS software and haplotype analysis was assessed using SHEsis software.
RESULTS
The rs2495636 GA genotype frequency in PTB patients was significantly decreased, and rs5946039 A allele was related to the lower risk of PTB. In gene, rs20541 variant was found to be associated with PTB risk under recessive mode. Moreover, rs141573089 C allele was significantly lower in PTB presenting with fever, drug resistance, and CC genotype was decreased in PTB presenting with leukopenia. rs2495636 polymorphism was associated with drug resistance, pulmonary infection, and rs3795175, rs638376 polymorphisms were related to drug resistance in PTB patients.
CONCLUSION
rs20541, rs2495636, rs5946039 polymorphisms might be contributed to the genetic background of PTB in Chinese population.
目的
本研究旨在探讨[具体基因1]、[具体基因2]和[具体基因3]基因多态性与肺结核易感性及其临床特征的关系。
方法
采用改良多重连接酶检测反应（iMLDR）对476例肺结核患者和473例对照进行9个单核苷酸多态性（SNP）基因分型。使用SPSS软件分析这些SNP与肺结核风险的关联，并使用SHEsis软件评估单倍型分析。
结果
肺结核患者中[具体基因1] rs2495636的GA基因型频率显著降低，[具体基因2] rs5946039的A等位基因与较低的肺结核风险相关。在[具体基因3]基因中，发现rs20541变异在隐性模式下与肺结核风险相关。此外，在发热的肺结核患者中[具体基因4] rs141573089的C等位基因显著降低，在白细胞减少的肺结核患者中CC基因型降低。[具体基因1] rs2495636多态性与耐药性、肺部感染相关，[具体基因5] rs3795175、rs638376多态性与肺结核患者的耐药性相关。
结论
rs20541、[具体基因1] rs2495636、[具体基因2] rs5946039多态性可能与中国人群肺结核的遗传背景有关。
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